Angiopoietin-like protein 2 (Angptl2) is a member of angiopoietin-like protein family, whose rhythmical expression or secretion helps maintaining body homeostasis, and is associated with coronary heart disease (CHD), abdominal aortic aneurysm (AAA), vascular inflammation and arteriosclerosis obliterians of lower extremity. Thus, it is of great significance for the studies concerning Angptl2. This article reviewed the role of Angptl2 in the pathogenesis of arteriosclerosis obliterians.