Chemokine C-C motif ligand 7 (CCL7) is widely expressed in mononuclear cells, T lymphocytes, dendritic cells and other immune cells. CCL7 was regarded as inflammatory factor at first, but with further studies, evidence shows that it may play significant roles in immune regulation, tissue regeneration, interaction with heparin sulfate, and promoting fibrosis. Therefore, it is of great significance to investigate the functions of CCL7 in the molecular mechanisms and treatment of disease. With the progresses of the multipotent stem cells and progenitor cells in clinical practice, CCL7, as an important factor to induce their differentiation, may has the potential to enhance the efficiency and therapeutic benefits of cell therapy. This article reviewed the structure and functions of this chemokine.