Objective To investigate whether antihypertensive medication and continuous positive airway pressure (CPAP) treatment can effectively control blood pressure (Bp) in the hypertensive patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods A total of 180 hypertensive patients with OSAHS admitted in the First Affiliated Hospital of Nanjing Medical University from January 2014 to June 2016 were recruited in this study. According to the outcome of hypertensive medication, they were divided into Bp controlled group (n=87) and Bp uncontrolled group (n=93). Then they were given CPAP treatment and hypertensive medication simultaneously for 6 months. Bp control results were compared among the patients undergoing different regimens of antihypertensive medications, and the relationship of Bp well-control with CPAP treatment was analyzed. Results A total of 13 different antihypertensive regimens were used among the enrolled subjects. There was no statistical difference in the regimen distribution between the Bp controlled group and Bp uncontrolled group (P>0.05). Multivariate factor logistic regression analysis revealed that antihypertensive regimen was not an independent predictor of Bp control outcome in the hypertensive patients with OSAHS (OR=1.897,P=0.094). However, CPAP treatment obviously decreased nocturnal systolic blood pressure (SBP) and diastolic blood pressure (DBP) in both the Bp controlled and uncontrolled groups (P<0.01). Conclusion In hypertensive patients with OSAHS, there is no significant association between antihypertensive medication regimens and Bp control. Additional CPAP treatment could further reduce nocturnal Bp in both Bp controlled and uncontrolled patients after antihpertensive medication.