Objective To investigate the status and influencing factors of metabolic syndrome (MS) among all faculty of a medical university in order to provide scientific references for prevention and control of the disease. Methods Cross-sectional survey was carried out to collect the physical examination results of all official serving employees from a medical university and their social demographic data. The physical examination results included their height, body mass, body mass index (BMI), blood pressure, blood glucose, blood lipids and other indices. Results There were 21 staffs having MS, with a prevalence of 6.5%, lower than the result of national survey (168%). They had significantly higher body mass, BMI, systolic blood pressure and diastolic blood pressure when compared with the non-MS subjects (P<005). Multivariate logistic regression analysis indicated that over 45 years old (OR=395, P<005) and male (OR=547, P<005) were independent risk factors for MS. Conclusion Multiple measures should be implemented to prevent and control MS. Paying attention to the changes of blood pressure, blood glucose, blood lipids and other indices, and timely diagnosing and treating MS are ideal measures.