The pathophysiological basis of heart failure (HF) is ventricular remodeling on the basis of inflammation and fibrosis. In recent years, evidence shows that galectin-3 plays an important role in the mechanism of cardiac regulation and has been recognized as a biological predictor for HF prognosis because its expression level reflects the severity and hierarchical of HF. However, its effect in the treatment of HF remains unclear. This article reviewed the studies on the correlation of galectin-3 and HF in order to provide new therapy ideas for clinicians.