At present, the results of angiography is mainly used for clinical assessment of coronary artery, but there are limitations of the method for the assessment of complex coronary lesions, such as critical lesions, eccentric lesions and diffuse lesions. However, coronary physiological function can well solve these problems and help clinicians make more accurate diagnosis and treatment. Therefore, this article summarized the main invasive indictors for clinical assessment of physiological functions of coronary artery in the catheterization room, in order to enable the readers to understand the significance of these indicators objectively.