Objective To determine the effect of levosimendan on the hemodynamics in the patients who suffered from acute myocardial infarction with heart failure. Methods A total of 112 patients with ischemic heart disease treated in our hospital from August 2012 to November 2014 were recruited in this study, and then randomly divided into control group and levosimendan group, with 56 cases in each group. The control group was treated with conventional diuretic and vasodilator therapy, while the levosimendan group was given levosimendan in addition. Pulse-indicated continuous cardiac output (PICCO) monitoring system was used to measure cardiac index (CI), global end-diastolic volume index (GEDI), and systemic vascular resistance index (SVRI), and the results were compared between the 2 groups. Left ventricular ejection fraction (LVEF) was detected by color Doppler ultrasound examination, and the changes of brain natriuretic peptide (BNP) and heart function improvement were observed at the same time. Results LVEF, CI, GEDI, SVRI and BNP were significantly improved in the both groups after treatment, and those of the levosimendan group were more significant than those of the control group (all P＜005). The total significant efficiency was obviously higher in the levosimendan group than in the control group (92.85% vs 66.07%, P＜005). Conclusion Levosimendan exerts short-term improvement in hemodynamics of acute myocardial infarction patients with heart failure.