Objective To observe the clinical efficiency of endovascular treatment for Trans-Atlantic Inter-Society Consensus (TASC) type C occlusion of superficial femoral artery (SFA) or more than 70% stenosis and the outcomes in 1 year’s follow up, and investigate the relevant factors of in-stent restenosis (ISR). Methods Clinical data of 58 cases(58 limbs) suffering from TASC type C occlusion of SFA or more than 70% stenosis in our hospital from May 2011 to May 2014 were collected and retrospectively analyzed. All of them received endovascular balloon dilatation and stent implantation. According to whether there was any occlusion or more than 70% stenosis in 1 year postoperatively, the patients were divided into patency group and re-occlusion group. Clinical data were compared and analyzed between the 2 groups. Results No perioperative death was found in the 58 patients. Out of 58 limbs there were 6 limbs not getting patency, with a patency rate of 89.7%. In 1 year’s follow-up, there were 41 cases with complete follow-up, and 30 of them were accordingly assigned to the patency group and the other 11 to the re-occlusion group. There was significant difference in ankle-brachial index between the 2 groups [(0.55±0.16) vs (0.41±0.24), P＜0.05]. Though there were no significant differences in the ratio of smokers and Fontaine stage between them, the P value was comparatively smaller, which might suggest that the 2 indices were associated with ISR. Conclusion Endovascular treatment is safe and effective in the treatment of TASC type C occlusion of SFA. The severity of vascular disease is associated with restenosis.