Objective To summarize our experience in the therapeutic options for femoral artery pseudoaneurysms (FAP). Methods Clinical data of 53 FAP patients admitted in our department from March 2005 to May 2015 were collected and retrospectively analyzed. Thirty-eight cases (71.7%) were iatrogenic injury, 8 (15.1%) were Bechest’s disease, 4 (7.5%) and 3 (5.7%) were due to trauma and infection. The cohort received surgical therapy, endovascular treatment and ultrasound-guided thrombin injection (UGTI). Results UGTI was performed on 17 cases (32.1%), with a success rate of 88.2%. Open surgery was carried out on 27 cases, with an overall complication rate of 37.0%, and no perioperative death was observed. Endovascular treatment was performed on 9 cases (17.0%), with a success rate of 100.0%, and no perioperative complication was observed. During the follow-up, the overall 3-year cumulative patency rate was 94.3%, and 3-year overall survival rate was 94.0%. Conclusion UGTI is the optional method for uncomplicated FAP. Surgical treatment still remains irreplaceable for complicated FAP, but the perioperative complication rate is quite high. Endovascular treatment can be employed for the pseudoaneurysms located far from the femoral artery bifurcation or the critically ill patients in emergency.