Alzheimer’s disease (AD), as the main cause of senile dementia, has become a serious threat to human health. Epidemiological evidence shows that curcumin is of g)reat effectiveness for AD, and it attracts much attention because of its great safety since it is derived from human food source. This article reviewed the therapeutic value of curcumin for AD based on the pathological changes of AD after curcumin treatment, the pharmacokinetics of curcumin and methods to increase its bioavailability.