Objective To investigate the clinical features of mantle cell lymphoma (MCL) and the prognostic factors in order to guide the clinical practice. Methods Clinical data of 18 patients with MCL admitted in our hospital from July 2008 to July 2014 were collected and retrospectively analyzed in this study. Their sex, age, B symptoms, invasion of bone marrow, scores of Mantle Cell Lymphoma International Prognostic Index (MIPI), Eastern Cooperative Oncology Group (ECOG) scores, serum levels of Ki-67 and lactate dehydrogenase (LDH), white blood cell (WBC) and lymphocyte (LYM) counts, clinical stages, initial therapy and clinical outcomes were analyzed. Fisher exact test was used to compare the cumulative survival. Kaplan-Meier survival analysis was employed to draw survival curve. The prognostic factors were analyzed by Cox proportional hazard model. Results Age (younger or older than 65 years, P＝0.036), MIPI scores (low-, medium- and high-risk, P＝0.049) and Ki-67 level (＜30% and ≥30%, P＝0.001) were correlated with prognosis, but sex, ECOG scores, B symptoms, β2-microglubulin, LDH level, WBC count, LYM count, clinical stages and initial therapy were not (P＞0.05). Conclusion Younger than 65 years, low or medium MIPI scores and Ki-67 below 30% are favorable prognostic factors for MCL.