Objective To analyze the different causes of death and influencing factors for non-Hodgkin’s lymphoma (NHL) in order to provide reference for clinical practice. Methods Clinical data of 76 patients who died of NHL in our hospital from January 2004 to December 2014 were collected and retrospectively analyzed to summarize the causes of death. Univariate analysis was performed to estimate single-factor based on cause of death, and the obtained related factors further underwent multivariate logistic analysis. Results Ann Arbor Ⅳ phase and B symptoms were the independent risk factors for the organ failure induced death. The combined diabetes and primary lymph nodes tumor were the independent risk factors for the infection induced death. Conclusion NHL patients should be properly evaluated before the treatment. Attention should be paid to high-risk factors related to death in order to improve the prognosis.