Objective To investigate the clinical features and associated factors in Parkinson’s disease (PD) accompanied with depression. Methods All the 178 patients with identified PD admitted in the Department of Neurology and Department of Geriatrics of Beijing Tiantan Hospital from October 2013 to February 2015 were recruited in this study. According to the results of Hamilton Depression Scale-24 (HAMD-24), they were divided into depression group (n＝107) and non-depression group (n＝71). Both groups were evaluated by motor symptoms and complications, non-motor symptoms, activities of daily living and quality of life. Results Depression group had remarkable differences with non-depression group in education level (P＜0.05), disease duration (P＜0.05), score of unified Parkinson’s disease rating scale Ⅲ (UPDRS-Ⅲ, P＜0.001 ), Hoehn-Yahr (P＜0.01), score of UPDRS-Ⅳ (P＜0.001), score of Montreal cognitive assessment (MoCA, P＜0.05), result of 14 items fatigue scale (FS-14, P＜0.001), result of rapid eye movement sleep behavior disorder screening questionnaire (RBDSQ, P＜0.01), result of restless leg syndrome rating scale (RLSRS, P＜0.001), score of UPDRS-Ⅱ (P＜0.001), result of 39 items Parkinson’s disease quality of life questionnaire (PDQL-39, P＜0.001), and incidence of anxiety (P＜0.05). Logistic regression analysis showed that the scores of Hamilton anxiety Scale (HAMA, OR＝1.282, P＜0.001) and UPDRS-Ⅱ (OR＝1.149, P＜0.05) were the risk factors for PD with depression. Conclusion PD patients with depression have higher incidences of motor symptoms and complications than non-depression PD patients, and are prone to anxiety, cognitive impairment, sleep disorders, fatigue, restless legs and other non-motor symptoms. Anxiety and reduced activities of daily living increase the risk of PD with depression. Depression exerts serious impact on quality of life in PD patients.