With profound understanding of Parkinson’s disease (PD), non-motor symptoms have been considered as an important part of its symptomatology. In addition to the high prevalence, the occurrence of hyposmia may also be used to differentiate PD from atypical and secondary parkinsonism. Studies on the gastrointestinal symptoms among PD patients showed that the risk of PD was increased to six-fold in people with constipation, and the α-synuclein deposition and Lewy bodies were found in the enteric nervous system. psychiatric symptoms such as rapid eye movement (REM) sleep behavior disorder (RBD), depression, anxiety and hallucinations, and delusions significantly impaired the quality of life in PD patients, and those patients with idiopathic RBD were at approximately higher risk for PD and other neurodegeneration diseases. Non-motor symptoms may become a breakthrough in early diagnosis of PD and should be paid more attention.