Objective To investigate the relationship of prostate volume (PV) with metabolic factors in healthy older men. Methods A total of 132 older men with whole clinical data of health examination from the Health Check-up Center in our hospital from May 2010 to July 2011 were recruited in this study. Their age ranged from 60 to 89 (71.00±8.96) years. The data, including age, height, body mass and blood pressure were recorded, and body mass index (BMI) was calculated. Three positions of PV were measured through abdominal ultra-sound imaging, and PV was calculated in the formula of transverse diameter×longitudinal diameter×anteroposterior diameter×0.52. Fasting plasma glucose (FPG), glycosylated hemoglobin A1c (HbA1c), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and serum uric acid (SUA) were measured. Statistical analysis was performed using SPSS for Windows version 16. Results Age and systolic blood pressure (SBP) were positively correlated with PV (P＜0.05), but BMI, diastolic blood pressure (DBP), and the levels of LDL-C, HbA1c, FPG and SUA had no obvious association with PV (P＞0.05). Conclusion SBP and age are risk factors for benign prostatic hyperplasia in aged men, but BMI, DBP, LDL-C, HbA1c, FPG and SUA are not related to PV in our cohort.