In this review, we elucidated the causes, diagnosis and treatment of post-stroke depression. Its incidence ranges from 20% to 60%. It mainly results from brain damage, neurotransmitter imbalance, and psychological imbalance after stroke. This disease may not only result in aggravated somatic symptoms, causing mental suffering, but also reduce the patients’ quality of life, further affecting their treatment and rehabilitation. Its treatment should adopt comprehensive intervention. The diagnosis and treatment for the disease should be strengthened in the future, and what’s more, more efforts should be paid on its management and prevention measures.