Objective To evaluate the nephrotoxic effects of domestic iodixanol injection in the elderly patients with coronary heart disease (CHD). Methods A multicenter, single blind, randomized controlled clinic trial was prospectively carried out in 5 hospitals in Liaoning Province from July 2013 to March 2014. Eighty-eight patients of 60 to 75 years old with CHD undergoing percutaneous coronary intervention (PCI) were divided into 2 groups: experimental group (domestic iodixanol injection group, n＝44) and control group [Visipaque (trade name of iodixanol) group, n＝44]. The clinical information including age, gender, body mass index (BMI), serum creatinine (SCr) and blood urea nitrogen (BUN) was recorded before PCI. Their SCr and BUN were determined in 48 h after PCI for renal function in the patients of the 2 groups. Results All of them underwent PCI smoothly, with a successful rate of 100%. There was no significant difference in the age, gender, BMI, SCr and BUN between the 2 groups before PCI (P＞0.05). No difference was found in the renal function in the 2 groups before and after PCI (P＞0.05). One patient of each group had nausea and vomiting respectively just in the day after operation, and recovered on the next day. None of patient had contrast-induced acute kidney injury or other adverse reactions. Conclusion Domestic iodixanol injection is safe for old patients with CHD underwent PCI.