We successfully rescued a patient suffering from extensive anterior wall ST-segment elevation myocardial infarction (STEMI) complicated with cardiogenic shock on the basis of diabetes mellitus. The initial symptom at onset was persistent chest pain, followed by blood pressure decline and profuse sweating soon after. Extensive anterior wall STEMI was confirmed by electrocardiography (ECG), myocardial enzymes test and coronary angiography. During the therapeutic process, he was found complicating with acute left ventricular failure, severe pneumonia, lactic acidosis and diabetic ketoaeidosis. Left anterior descending branch was reopened by emergency percutaneous coronary intervention (PCI). Intra aortic balloon pump (IABP) and noninvasive ventilator were employed for life support. Heart failure attacked repeatedly and pneumonia was protracted. Finally the patient got better and discharged after 41 days’ therapy in the coronary care unit.