Due to organ dysfunction and comorbidity of chronic diseases, the elderly are more susceptible to multiple organ failure in the elderly (MOFE), under the circumstance of stimulus, such as acute exacerbation of lung infections and chronic diseases of heart, brain, kidney and other organs. Microcirculation disorder is currently considered not only as the most important underlying mechanism resulting in MOFE, but also as the core link of the process of concurrent MOFE. The modern viewpoint thinks that early microcirculation function monitoring and microcirculation as target for treatment have become new strategies for MOFE treatment in the elderly patients.