Objective To investigate the related risk factors of renal-cardiac syndrome (RCS) in the elderly patients with chronic kidney disease (CKD) in order to provide preventive strategies for RCS. Methods Clinical data of 222 elderly patients with CKD admitted in Chinese PLA General Hospital from March 2010 to March 2013 were collected and retrospectively analyzed. Logistic regression analysis was used to study the related risk factors of RCS. Results The incidence of RCS was 25.2% in this cohort. Univariate analysis showed that age, renal function stage, history of diabetes, hypertension, anemia, and malnutrition were related with the occurrence of RCS, while sex, smoking, history of cerebrovascular disease, duration of CKD, dyslipidemia and other factors had no obvious correlation with RCS (P＞0.05). Multivariate logistic regression analysis showed that, age, renal function stage, diabetes, hypertension, and anemia were independent risk factors for RCS. Conclusion CKD patients with advanced age (≥80 years), advanced renal dysfunction (≥stage 3B), diabetes, hypertension and anemia are of high risk of RCS. Therefore, special attention should be paid to the evaluation and control of above-mentioned risk factors.