Objective To analyze the correlation of plasma level of soluble thrombomodulin (sTM) and glomerular filtration rate (GFR) in healthy elderly. Methods A total of 283 healthy elderly subjects (＞65 years) were selected by cluster sampling from 9 communities of Beijing. Their plasma levels of sTM were measured by ELISA. Their estimated GFR (eGFR) was evaluated with Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. And also, their anthropometric measurements and serum biochemical indices were measured. Pearson and Spearman correlation tests and multiple linear regression analysis were used to analyze the data and their correlations. Results eGFR had negative correlation with plasma sTM, age, urea nitrogen, C-reactive protein (CRP), and systolic pressure in these subjects, and had positive correlation with albumin, high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C). After adjusting age, blood pressure, blood glucose (GLU), CRP, blood lipid, uric acid (UA) and the other factors in the multiple linear regression, a negative correlation was still seen between plasma sTM and eGFR in the elderly (B＝-3.340, P＝0.000). When the cohort of patients was divided into elderly (65 to 80 years) and very elderly groups (＞80 years), there was no difference in eGFR and plasma sTM between them. While negative correlation of eGFR with plasma sTM was still seen within both groups (r＝-0.229, P＝0.000；r＝-0.3613, P＝0.02). And the negative correlation was still observed after adjusting age, blood pressure, GLU, CRP, blood lipid, and UA (B＝-3.26, P＝0.000；B＝-4.45, P＝0.013). Conclusion The plasma level of sTM may be used as an index of renal function decline in healthy elderly.