Impaired glucose tolerance (IGT) is the most common form of impaired glucose regulation, and accounts for major proportion of people with prediabetes. People with IGT are at high risk for type 2 diabetes mellitus, and 10% to 15% of them will progress into diabetes every year if not receiving effective intervention. But if they are treated properly, this process can be delayed or even reversed to normal healthy state. People with IGT are also vulnerable for cardiovascular diseases. Clinical evidence shows that they are prone to suffer from cardiovacular events than those with normal glucose tolerance. So for the people with IGT, active and effective intervention must be carried out to prevent diabetes and cardiovascular events. Life style intervention should be of the first choice to intervene IGT, and drugs can be added if life style intervention fails to meet the target.