Objective To investigate the clinical features of coronary lesions in the super-aged patients with coronary artery disease(CAD), and the correlation of the features with cardiovascular risk factors. Methods Totally 391 patients who were diagnosed as CAD undergoing pereutaneous coronary intervention (PCI) in our department from May 2011 to August 2012 were divided into aged group (71 to 79 years old, n＝275), and super-aged group (≥80 years old, n＝116). Their clinical and interventional procedure data were analyzed respectively. Results Compared with the aged group, the super-aged group had a higher incidence of heart failure (25.9% vs 11.3%), higher rate of preoperative positive troponin T (cTnT) (41.4% vs 28.4%), higher levels of high density lipoprotein cholesterol (HDL-C) [(1.19±0.35) vs (1.12±0.29)mmol/L], higher increase of creatinine concentration after the operation [(1.84±17.5) vs (-2.01±12.2)μmol/L], higher proportion of ST-segment elevation myocardial infarction (STEMI) (21.6% vs 13.5%), and higher Gensini score [(45.62±31.18) vs (40.48±28.12); P＜0.05 for all]. Among these 391 patients, male, diabetes, and high level of creatinine were positively related with the higher score of Gensini (P＜0.01 for all), so was serum level of lipoprotein a [Lp(a); P＜0.05], while HDL-C was negatively correlated with the score (P＜0.05). Serum cystatin C (Cys C) was negatively associated with estimated glomerular filtration rate (eGFR; r＝-0.509, P＜0.01). For those with eGFR≥60ml/(min·1.73m2), their serum level of Cys C was significantly lower than those with eGFR＜60ml/(min·1.73m2) [(1.30±0.26) vs (2.01±0.53)mg/L, P＜0.05]. Conclusion Super-aged patients with CAD are always complicated with heart failure, acute coronary syndrome, and severe coronary lesions.