Objective High serum uric acid level (SUA) and chronic kidney disease (CKD) are the risk factors that resulted in coronary heart disease (CHD). It is not clear whether the interaction between SUA and CKD is the risk factor of CHD. This study aimed to assess the correlation between severity of coronary artery stenosis and CKD with different level of SUA [man＞417μmol/L (7.0mg/ml), woman＞357μmol/L (6.0mg/ml)]. Methods A total of 214 randomly selected patients with coronary arteriography-identified CHD who admitted in our center from January 2011 to September 2012 were subjected in this study. The patients with CHD were grouped according to the value of estimated glomerular filtration rate (eGFR). The patients’ serum uric acid, clinical features, serum creatinine, inflammatory factors and some metabolism related variables were analyzed. eGFR was calculated with the formula of MDRD. The definition of CKD was defined as whether the patient’s kidney was impaired or not and GFR＜60ml/(min·1.73m2) for more than 3 months. The severity of coronary artery stenosis was assessed by the result of Gensini scale with coronary angiography. All P values were two-tailed and P＜0.05 was deemed statistically significant. Results Among the 214 patients enrolled, 82 cases (38.3%) had CKD. eGFR was negatively correlated with the severity of coronary artery stenosis (r＝-0.536, P＜0.001). SUA was positively correlated with the severity of coronary artery stenosis in CKD patients (r＝0.29, P＜0.01). Logistic regression analysis showed that the independent risk factors of CKD were SUA (OR＝1.22, 95% CI 1.09-1.37, P＜0.001), age (OR＝1.11, 95% CI 1.10-1.14, P＜0.001), coronary artery stenosis (OR＝0.83, 95% CI 0.79-0.85, P＜0.001), and history of hypertension (OR＝1.90, 95% CI 1.40-2.60, P＜0.001). Conclusion Hyperuricemia may be an important factor of aggravating coronary artery stenosis in CKD, and may be involved in every stage of the disease.