Although the human heart is metabolically one of the most active organs in the body, the heart has a relatively low ATP content. Accordingly, the heart has low tolerance for energy deficiency. The regulation of myocardial metabolism is linked to multiple factors, including substrates concentration, hormone concentrations, coronary blood ?ow and nutritional status of the tissue, etc. Dysglycemia, hyper/hypo-thyroidism and hyperuricemia are all involved in the pathophysiological process of heart energy metabolism. Although hyperglycemia on admission is a powerful independent predictor of survival in patients with coronary heart disease, intervention to normalize glycemia has yielded inconsistent results. Indeed, recent large randomized controlled trials have failed to show a significant decrease in mortality with intensive glycemic control, or have even shown an increased mortality risk. “Heart and metabolism” is a rising discipline. We choose “Heart and Metabolism” as the topic of the special columm in this issue and want to have it account for a modest spur to induce others to come forward with valuable contributions.