As an integral part of stress response，inflammatory processes are composed of several inflammatory mediators such as cytokines, prostanoids, free radicals, and some transcription factors, and are under the control of the neuroendocrine and autonomic nervous systems. During chronic inflammatory processes related to stress, the interaction between cytokines and the HPA axis results in GC resistance, which leads not only to the hyperactivation of the HPA axis (characterized by elevation of GCs and CRH) but also to a self-amplifying vicious cycle of inflammatory response. And these inflammatory processes within the context of stress also represent the common physiopathological mechanisms in stress-related diseases, such as psychiatric disorder and cardiovascular disease.