Pancreas is the important gland with both endocrine and exocrine function, which plays a very important role in digestion, absorption and substance metabolism. The morphologic and functional changes of the aged pancreas appear to be concomitant decrease in functional capacity. In elderly population, dyspepsia is common with many reasons. This article describes the performance and functional changes in aging pancreas, explore the effects of pancreatic exocrine function on dyspepsia after pancreatic aging, and give a brief review about the relationship between pancreatic aging and dyspepsia.