Genetic factors play important roles in the development of Alzheimer?s disease(AD). We mainly introduced some genes, which has been reported in recent years, predisposing to different aspects of AD. Besides, from the aspects of epigenetics, gene or drug therapy, we also discussed how to block the expression pathway of some predisposing genes, so as to inhibit or delay the development of AD. Except several genes related to familial AD and apolipoprotein E, some other predisposing genes related to sporadic AD remains controversal. Racial diversity and sample size might explain the disagreement of various researches. Therefore, further studies are needed for better diagnosis and gene therapy of AD.