Objective To evaluate the effects of interventional therapy for 1eft iliac vein compressed syndrome in elderly patients. Methods Fifty cases of 1eft iliac vein compressed syndrome underwent stent placement and balloon angioplasty through the femoral vein. For patients who had thrombosis, an inferior vena cava (IVC) filter device was placed firstly and transcatheter thrombolysis via the popliteal vein was performed, then 1eft iliac vein compressed syndrome was treated sequentially. For patients with varices, staged saphenous vein high ligation and stripping was carried out. Results The stenosis or occlusive segments of left iliac vein were suc-cessfully dilated in 39 cases, of which 30 cases received stent implantation, and no in-hospital death or pulmonary embolism was reported. The leg swelling was greatly relieved at discharge. Thrombus disappeared completely in 15 cases and partly in 2 cases. Post-thrombosis syndrome was reported in 4 cases. The symptoms of varicose vein were dramatically lessened. Leg ulcers healed completely in 7 cases. Among 41 cases who had follow-up results, in-stent thrombus formation was observed in 2 case, and in-stent restenosis and stent displacement in 1 case. Conclusion Interventional therapy for 1eft iliac vein compressed syndrome in elderly patients has the advantages of less trauma, quick recovery, and less complications. The short-term efficacy is satisfactory, and long-term efficacy still needs further study.