Objective To investigate the levels of plasma estrogen,C-reactive protein (CRP) and interleukin (IL)-6 in postmenopausal female patients with coronary heart disease (CHD) and the association of estrogen level with CRP and IL-6 levels.Methods The plasma levels of estrogen,CRP and IL-6 were measured in 31 postmeno-pausal females with CHD and 44 ones without CHD.Results Plasma level of estrogen was obviously lower (18±7)vs (24±10)ng/L,P<0.05,while levels of CRP and IL-6 were obviously higher (6.9±5.9)vs (1.9±1.3)mg/L;(59±11) vs (46±13) ng/L,P<0.01 in CHD patients than in non-CHD ones.The plasma level of estrogen had no association with that of CRP and IL-6 (r=-0.106,-0.203,P>0.05 ).Conclusion Estrogen,CRP and IL-6 play important roles in the pathogenesis of CHD in postmenopausal female patients.The effect of estrogen on the pathogenesis of CHD in female patients has no association with CRP and IL-6.