Objective To evaluate the safety and efficacy of ascorbic acid in reducing the risk of contrast-induced nephropathy in the elderly renal insufficiency patients who were scheduled to undergo coronary angiography.Methods We conducted a single-center,prospective,randomized,controlled trial.A total of 132 consecutive elderly patients with stable serum creatinine levels of at least 11 mg/L(≥97.2 μmol/L),scheduled to undergo coronary angiography,were randomized into ascorbic acid (n=70) and control groups (n=62).In ascorbic acid group,patients received intravenous hydration of ascorbic acid (3 g) before the procedure and oral hydration of ascorbic acid after the procedure (0.5 g once,1 g/d,2 days).In control group,sodium chloride alone was given.The patients’ renal function and cardiovascular events after the procedure were compared between the two groups.Results There was no difference between ascorbic acid group and control group in primary end point,the mean peak increase in serum creatinine measured within 48 hours after coronary angiography (0.2±1.7) vs (0.3±2.2)mg/L,P= 0.625.The incidence of contrast-induced nephropathy,a secondary end point,was 5.6% (4/70) in ascorbic acid group and 8.1% (5/62) in control group,with no significant difference between the two groups (P=0.594).There was either no difference between the two groups in the in-hospital clinical outcomes or length of hospital stay.Conclusion For the elderly patients with renal insufficiency who were scheduled to undergo coronary angiography,short-term application of high-dose ascorbic acid could reduce the incidence of contrast-induced nephropathy.?更多