Objective To explore the association between job stress and myocardial infarction.Methods A total of 260 subjects were investigated,including 164 cases of myocardial infarction and 96 controls.In this case-control study,job stress in the past career was measured by effort-reward imbalance(ERI) model,and coronary heart disease was diagnosed by combination of clinical manifestation and angiography.The association between job stress and myocardial infarction was explored by the multivariate analysis.Results Compared with the baseline,high effort,high ERI or high overcommitment increased the risk of myocardial infarction.The odds ratio(OR) was 2.4(95%CI 1.2-5.2),2.8(95%CI 1.3-6.1),and 2.7(95%CI 1.2-5.8),respectively,after adjustment for age,gender,primary hypertension,hyperlipidemia,diabetes mellitus,family history of coronary heart disease,smoking,body mass index,education and marriage.The combination of high ERI and high overcommitment led to the highest risk of coronary heart disease with adjusted OR 4.9(95%CI 1.7-14.2).Job stress affected the risk of myocardial infarction in a dose-dependent manner.Conclusion Job stress increases the risk of myocardial infarction,and it is probably a new potential important risk factor of myocardial infarction.?更多