Objective To examine the risk factors and outcome of post-stoke depression(PSD)and to analyze the personality of the elderly PSD patients using Minnesota Multiphasic Personality Inventory.Methods A total of 160 elderly PSD patients were analyzed retrospectively.The risk factors were analyzed using logistic regression analysis.The personality of the elderly PSD patients was also assessed.Results The scores on personalities of suspicion and depression were significantly different between PSD and non-PSD cases(P<0.05),which were positively Correlated with PSD in the elderly cases.Spouse support,PSD sites,mini-mental status examination,and National Institutes of Health stroke scale were associated with PSD in the elderly.Rankin score and Bathel index between PSD and non-PSD patients were significantly different(P<0.05).Conclusion The personalities of suspicion and depression are predominant in the elderly PSD patients.No spouse support,lesion of anterior circulation,cognitive disorder,and severe stoke are risk factors for PSD in the elderly cases.PSD in the elderly cases postpones hospitalization duration and predicts worse clinical outcome.