Objective To analyze retrospectively the application of Perclose Proglide vascular closure devices in patients with marked distortion of iliac artery after coronary artery angiography (CAG). Methods Eighty patients with marked distortion of iliac artery were selected from 3760 CAG cases from August 2005 to December 2007. Only when 0.038" extra-support wire(TERUMO:Radifocus Guide Wire M) and/or 23 cm long sheeth (ST-Jude Medical) was used,CAG achieved all success for 80 patients. Perclose Proglide vascular closure devices were used in 35 cases,and the other 45 cases received traditional manual compression. The hematoma,bleeding,aneurysm and infection rate were compared between the two groups. Results All patients who used Perclose Proglide vascular closure devices achieved success,with 2 cases of hematoma and 1 case of bleeding,without aneurysm and infection. The hematoma,bleeding and aneurysm in control group were 3,1 and 1 cases,respectively. There was no difference between two groups. Conclusion It is safe and effective to use Perclose Proglide vascular closure devices in patients with marked distortion of iliac artery after CAG.