Objective To assess the value of global systolic strain in the evaluation of left ventricular systolic function by two-dimensional speckle tracking imaging. Methods Two-dimensional echocardiography was performed in 52 patients with heart failure and 30 healthy control subjects. The systolic longitudinal strain (LS),radial strain (RS) and circumferential strain (CS) were measured in 18 segments of left ventricular using 2D strain software. The global longitudinal strain (GLS),global radial strain (GRS) and global circumference strain (GCS) were calculated as the average of left ventricular 18 segmental LS,RS and CS values respectively. Left ventricular ejection fraction (LVEF) was also measured by the conventional two-dimensional echocardiography. Receiver operation characteristic curves (ROC) were obtained for GLS,GCS and GRS respectively to the cut-off values.Results The values of GLS,GRS and GCS in heart failure group were significantly decreased compared with those in control group (P<0.05). ROC curves showed that the areas under the GLS and GCS curves were 0.950 and 0.939,respectively. The corresponding GLS and GCS cut-off values were -13.12% and -13.86%. The sensitivity and specificity of GLS and GCS for diagnosis of heart dysfunction were 90.0%/94.4% and 93.3%/83.3% respectively. The area under GRS curve was just 0.17 (< 0.5),which had little diagnosis value in evaluating left ventricular systolic dysfunction.Conclusion Two-dimensional global systolic strain may help to evaluate left ventricular systolic function,in which,GLS and GCS have a significant value of diagnosis in heart dysfunction.?更多