Objective To investigate the clinical effect of percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) complicated with multiple organ dysfunction syndrome (MODS). Methods From January 2003 to December 2008,383 hospitalized patients with AMI and MODS in General Hospital of Shenyang Military Command were divided into PCI group (n=181) and drug treatment group (n=202). The baseline data,the incidence rate of each dysfunction organ,the number of dysfunction organs and the mortality were compared between the two groups. Results There were more AMI patients with elevated ST segment in PCI group than in drug treatment group (90.6% vs 83.2%; P=0.03). The other baseline data were identical between the two groups. The revascularization rate in PCI group was much higher than that in drug treatment group (98.3% vs 52.5%; P<0.01). The incidence rate of organ dysfunction,such as heart,lungs,kidneys,stomach and intestine,was not different between the two groups. But in liver,brain and hematological system,the organ dysfunction incidence rate was lower in PCI group than in drug treatment group (16.6% vs 27.2%,10.5% vs 18.8%,2.2% vs 7.4%; P<0.05). The incidence rate of 2 organs dysfunction was higher in PCI group than in drug treatment group (65.2% vs 54.5%; P=0.04). The incidence rate of 3 organs dysfunction was not different between the two groups. But the incidence rate of 4 or 5 organs dysfunction was lower in PCI group than in drug treatment group (9.4% vs 17.3%,2.2% vs 7.9%; P<0.05). The mortality in PCI group was much lower than that in drug treatment group (9.9% vs 36.1%; P<0.05). Conclusion Although patients with AMI and MODS have high risk and high mortality,the valid PCI treatment still displays satisfactory clinical effects.