Objective To investigate the myocardial protection effect of short-term high dose statin pretreatment during percutaneous coronany intervention (PCI) in elderly patients with non-ST-segment-elevation acute coronary syndrome (NSTEACS). Methods Ninety-two elderly NSTEACS patients admitted for PCI were randomized into high dose atorvastatin group (atorvastatin 40 mg/d,n=47) and control group (atorvastatin 10 mg/d,n=45). A 3 to 5-day pretreatment with atorvaststin was given to the subjects. The two groups were identical in other medication treatment. Before PCI,all subjects received oral administration of clopidogrel 300mg as a dose again.Levels of creatine kinase (CK),CK-MB and cTnI level were measured at baseline,8 and 24 h after the procedure. Major adverse cardiac events (MACE,including death,myocardial infarction and revascularization) at 30-day follow-up visit were analyzed. Results The levels of CK and CK-MB at 24 h were significantly lower in high dose atorvastatin group than in control group〔(3.2±0.5) vs (4.1±0.4) g/L,(0.31±0.09) vs (0.38±0.12) g/L,P<0.05〕,while they were not significantly different at 8 h between two groups. The proportion of patients with cTnI level above normal up-limit value and that with CK,CK-MB level above 3-fold normal up-limit at 24-hour was significantly lower in high dose atorvastatin group than in control group ( 8.5% vs 26.7%,6.4% vs 15.6%,6.4% vs 17.8%,P<0.05). MACE incidence at 30-day follow-up visit was lower in high dose atorvastatin group (12.8%) than in control group (17.8%),but with no significant difference. Conclusion High dose atorvastatin pretreatment provides myocardial protection during PCI in elderly patients with NSTEACS.?更多