Objective To investigate the relationship between microalbuminuria(MA) and severity of atherosclerotic coronary artery disease in patients with multiple cardiovascular risk factors. Methods We carried out a retrospective cross-sectional study. Totally 208 patients were chosen,including 149 (71.6%) patients with hypertension and 125 (60.1%) patients with coronary artery disease. The average age of the patients was (65.4±10.6) year. The patients who underwent selective coronary angiogram for being suspected of or excluded of coronary artery disease were investigated. The patients with macroalbuminuria were excluded. Urinary albumin to creatinine ratio (ACR) was measured. Modified Gensini score system was used to evaluate the severity of coronary artery atherosclerosis. Results The patients’ age,sex,systolic blood pressure ,HbA1c and hypersensitive C-reactive protein (hsCRP) levels were significantly different between MA+ and MA-groups. The patients’ age,sex,prevalence of hypertension,prevalence of diabetes mellitus,HDL-C,fast plasma glucose,2-h plasma glucose,HbA1c,and hsCRP levels,ACEI/ARB,and use of statin were significantly different between patients with various severity of coronary diseases. ACR were found to be positively correlated with Gensini score(r=0.232,P=0.001). In multi-variant linear regression model,sex,ACR and LDL-C(B=-25.0,0.3,9.2;P=0.002,0.006,0.041) were established as independent predictors of Gensini score,independent of age,smoking,hypertension,body mass index,waist-to-hip ratio,HDL-C,HbA1c and hsCRP. Conclusion MA is positively correlated with the severity of coronary artery atherosclerosis. ACR is proved to be an independent predictor of Gensini score,together with sex and LDL-C.?更多