Objective To observe the clinical effect of Xuebijing in the treatment of gastrointestinal dysfunction among elderly cases with multiple organ dysfunction syndrome(MODS).Methods Multicenter,randomized and control test was applied to 58 elderly patients with MODS who were assigned randomly to administration of Xuebijing group or control group.The intestinal dysfunction score,acute physiology and chronic health evaluationⅡ score(APACHE Ⅱ) and Marshall score were calculated before and after the test respectively.The prognosis within 28 d was recorded.Results The intestinal dysfunction score,APACHE Ⅱ score and Marshall score of all patients were decreased in both groups,but they were significantly better in treatment group than those in the control group.The effect on intestinal dysfunction was better in Xuebijing group.There was significant difference on the mortality in treatment group compared with that in the control group when APACHE Ⅱwas between 8 and 20 scores.Conclusion Xuebijing can improve gut barrier function and the prognosis of the elderly patients with MODS.