Abstract:Objective To explore the predictive value of triglyceride-glucose (TyG) index and atherogenic index of plasma (AIP) for revascularization after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD). Methods A retrospective analysis was conducted on 787 CHD patients undergoing coronary angiography in follow-up after drug-eluting stent implantation at the First Medical Center of Chinese PLA General Hospital from January 2018 to January 2020. According to need for revascularization or not, they were divided into a revascularization group (315 cases) and a non-revascularization group (472 cases). SPSS 25.0 and R 4.1.3 software were used for statistical analysis. Based on data type, rank sum test, Chi-square test or Fisher exact test was used for comparison between groups. Univariate Cox regression analysis was utilized to analyze the influencing factors for revascularization, and multivariate Cox proportional hazard regression analysis was applied to analyze whether TyG index and AIP are independent predictors of revascularization. A time-dependent receiver operating characteristics (ROC) curve was plotted, and the area under the curve (AUC) was employed to identify the predictive values of TyG index and AIP for revascularization after PCI. Results There were significant differences between the revascularization group and the non-revascularization group in terms of left ventricular ejection fraction (LVEF), smoking history, white blood cell (WBC) count, platelet (PLT) count, fasting blood glucose (FBG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), systemic immune-inflammation index (SII), TyG index, and AIP (all P<0.05). Univariate Cox regression analysis found that, history of atrial fibrillation, smoking history, WBC count, PLT count, FBG, TC, TG, LDL-C, SII, TyG index, and AIP were risk factors for revascularization, while LVEF and HDL-C was a protective factor for revascularization. Multivariate Cox proportional hazards regression analysis showed that after adjusting for confounding factors, the increases in TyG index and AIP were still associated with the risk of revascularization. Kaplan-Meier survival curve analysis indicated that the cumulative incidence rate of revascularization was significantly higher in the third quantile array of TyG index and AIP than in the first and second quantile arrays (all P_log-rank<0.001). Time-dependent ROC curve analysis revealed that in predicting revascularization, the AUC value of TyG index ranged from 0.571 to 0.618, that of AIP predicts was from 0.573 to 0.605, and the value of their combination was from 0.577 to 0.614 for revascularizatio. Conclusion TyG index and AIP have good predictive value for revascularization events in CHD patients after PCI.

Abstract:Objective To investigate the status quo of frailty and its influencing factors in the elderly patients with diabetic peripheral neuropathy (DPN). Methods The clinical data of 203 elderly DPN patients admitted to Qionghai Hospital of Traditional Chinese Medicine from September 2020 to September 2022 were retrospectively analyzed. The patients were divided into frailty group (n=58) and non-frailty group (n=145) according to the Physiological Frailty Assessment Scale and the differences in basic data and laboratory indicators between the two groups were compared. SPSS statistics 22.0 was used for data analysis. According to the data type, t test or χ² test was used to compare the groups. The predictive value of age and body mass index (BMI) for frailty in the elderly DPN patients was analyzed via receiver operating characteristic (ROC) curve. The risk factors of frailty in the elderly DPN patients were analyzed using multivariate logistic regression analysis. Results The proportion of women, those living alone or in nursing homes, unmarried/divorced/widowed, smoking, diabetic course≥ 10 years, anxiety or depression, sleep disorders, and other major or microvascular complications in the frailty group were significantly higher than those in the non-frailty group (χ²=11.106,15.304,20.382,23.889,12.931,9.633,33.274,7.337; P<0.05). Age of patients in frailty group was significantly higher than that in non-frailty group (t=22.653), and BMI was significantly lower than that in non-frailty group (t=2.621), with statistical significance (P<0.05). ROC analysis of age and BMI showed good predictive value for frailty in the elderly DPN patients, and the area under the curve was 0.986 (95%CI 0.974-0.998; P<0.05) and 0.898 (95%CI 0.856-0.940; P<0.05). Multivariate logistic regression analysis showed that women (OR=1.067,95%CI 1.002-1.136), living alone or in nursing homes (OR=3.450,95%CI 1.206-9.869), unmarried/divorced/widowed (OR=3.045,95%CI 1.524-6.084), smoking (OR=1.566,95%CI 1.038-2.363), diabetes≥10 years (OR=1.389,95%CI 1.174-1.643), anxiety or depression (OR=2.783,95%CI 1.250-6.196), sleep disorder (OR=1.305,95%CI 1.194-1.426), other major or microvascular complications (OR=4.197,95%CI 1.669-10.554), age≥70.360 years (OR=1.873,95%CI 1.249-2.809) and BMI≤20.185 kg /m² (OR=4.246,95%CI 1.588-11.353) were the risk factors for frailty in the elderly DPN patients. Conclusion Elderly DPN patients have a high risk of frailty, its occurrence is affected by multiple factors, and clinicians should pay attention to it in the treatment of such patients.

Abstract:Objective To investigate the incidence rate of intraoperative hypothermia in elderly patients undergoing major abdominal surgery and analyze the related factors for intraoperative hypothermia. Methods A total of 146 elderly patients who underwent major abdominal surgery in our hospital between January 2022 and January 2023 were recruited as the study subjects. The incidence of intraoperative hypothermia and its impact on postoperative complications were statistically analyzed. Logistic regression model was used to analyze the related influencing factors for intraoperative hypothermia in elderly patients undergoing major abdominal surgery. SPSS statistics 22.0 was employed for statistical analysis. Data comparison between 2 groups was performed using student′s t test or Chi-square test depending on data type. Results Among the 146 subjected patients, 76 cases (52.05%) experienced intraoperative hypothermia. The incidence rates of shivering during anesthesia recovery, metabolic acidosis and electrolyte disturbance were significantly higher in patients with intraoperative hypothermia than those with normal body temperature (P<0.05). Binary logistic regression analysis showed that body mass index ≥24 kg/m² (OR=0.212,95%CI 0.073-0.615) and warming infusion solutions (OR=0.459,95%CI 0.279-0.756) were protective factors, and anesthesia time ≥3 h (OR=2.010,95%CI 1.604-2.518) and intraoperative infusion volume >2 000 ml (OR=1.912,95%CI 1.164-3.139) were risk factors for intraoperative hypothermia in elderly patients with major abdominal surgery. Conclusion The incidence of intraoperative hypothermia is high among elderly patients undergoing major abdominal surgery, and it will increase the incidence rates of various postoperative complications. It is suggested that clinical composite measures should be adopted to reduce the incidence rate of intraoperative hypothermia.

Abstract:Objective To investigate the quality of life (QOL) in elderly patients with cervical radiculopathy and analyze its influencing factors. Methods A total of 163 elderly outpatients with cervical radiculopathy treated in our department from May 2020 to May 2023 were enrolled in this study. Chinese version of 36-Item Short Form Health Survey (SF-36) was used to investigate the QOL of the patients. SPSS statistics 20.0 was employed for data analysis. Depending on data type, student′s t test and analysis of variance were applied for intergroup comparison, and multiple linear regression analysis was conducted to analyze the factors affecting the QOL of elderly patients with radiculotic cervical spondylosis. Results The total score of QOL was(60.33±11.79)points in the 163 elderly patients with cervical radiculopathy. Univariate analysis showed that significant differences were observed in gender, time of sitting at a desk or with lowering head, education level, source of medical expense, course of disease, number of lesion segments, and Babinski reflex (P<0.05). Multiple linear regression analysis indicated that gender, time of sitting at a desk or with lowering head, education level, and course of disease were influencing factors for QOL in the elderly patients with cervical radiculopathy (t=4.693,2.513,3.022,4.663; P<0.05). Conclusion Elderly patients with cervical spondylotic radiculopathy have poor QOL. Gender, prolonged time of sitting at a desk or with lowering head, education level and course of disease are factors affecting their QOL. So, special attention should be paid to the patients with above factors in order to improve their QOL.

Abstract:Objective To investigate the compliance to rehabilitation training and its influencing factors in elderly patients after total knee arthroplasty (TKA). Methods The clinical data of 244 elderly patients undergoing TKA in our hospital from January 2022 to January 2023 were collected and retrospectively analyzed. All patients were assessed for rehabilitation training compliance in three months after surgery. The score of training compliance was compared in the patients with different clinical characteristics. Multivariate logistic stepwise regression analysis was used to analyze the risk factors affecting the compliance in the patients, and the obtained risk factors were employed to construct a risk prediction model. Receiver operating characteristics (ROC) curve was plotted to analyze the value of risk prediction models for rehabilitation compliance in the patients. SPSS statistics 22.0 was used to process the data, and student′s t test and F test were applied to compare the data between groups depending on data type. Results For the 244 elderly patients after TKA, the score of physical exercise compliance, active exercise seeking compliance and exercise supervision compliance was (13.27±3.09), (6.88±2.04), and (6.12±1.81) points, respectively. The total score of compliance to rehabilitation training was (23.27±6.94) points, with the lowest score of 15 and the highest one of 32. The total score of rehabilitation training compliance of the patients with female, aged ≥80 years, combined diseases >2, junior high school education level, no spouse, living alone, monthly income <500 Yuan and chronic pain was significantly lower than those of male, aged <80 years, combined diseases ≤2 or no, high school education level or above, having spouse, cohabitation with spouse or children or others, monthly income ≥500 Yuan, and no chronic pain (P<0.05). Multivariate logistic regression analysis confirmed that female (OR=3.544,95%CI 1.036-12.123), aged ≥80 years (OR=1.052,95%CI 1.024-1.081), combined diseases >2 (OR=4.418,95%CI 1.274-15.321), junior high school education (OR=4.274,95%CI 1.542-11.846), no spouse (OR=3.245,95%CI 1.244-8.465), living alone (OR=1.226,95%CI 1.105-1.360), monthly income <500 Yuan (OR=2.429,95%CI 1.442-4.092), and chronic pain (OR=2.015,95%CI 1.009-4.024) were risk factors for the compliance to rehabilitation training in elderly TKA patients. ROC analysis indicated that the constructed risk model had an area under the curve of 0.934, standard error of 0.014,95%CI of 0.907-0.961, best cut off value of 35.499, sensitivity of 0.925, specificity of 0.890 for predicting rehabilitation training compliance in elderly TKA patients. Conclusion Many factors affect the compliance to postoperative rehabilitation training in elderly TKA patients. ROC analysis confirms that our risk prediction model has a good predictive value for the compliance, which may be helpful for implementation of subsequent rehabilitation training for these patients.

Abstract:Objective To investigate the postoperative gastrointestinal dysfunction in the elderly patients with gastrointestinal tumor and analyze its influencing factors. Methods The clinical data of 185 patients with gastrointestinal tumors admitted to Heji Hospital Affiliated to Changzhi Medical College from May 2020 to May 2023 were retrospectively analyzed. The gastrointestinal function of the patients was evaluated according to intake, feeling nauseated, emesis, physical exam and duration of symptoms (I-FEED) scoring system. The I-FEED score < 6 or≥ 6 points represented the recovery group (n=105) and the delayed recovery group (n=80). SPSS statistics 20.0 was used for data analysis. According to the data type, the t test, ANOVA, or χ²test was selected for inter-group comparison. Multiple logistic regression was used to analyze the influencing factors of postoperative gastrointestinal dysfunction. Results The I-FEED score of 185 patients was (4.26±1.04) points, and the incidence of delayed gastrointestinal function recovery was 43.24% (80/185). Multiple logistic regression analysis showed that body mass index (OR=1.868,95%CI 1.235-2.825), preoperative albumin (OR=0.643,95%CI 0.455-0.908), intraoperative blood loss (OR=1.680,95%CI 1.044-2.705) and abdominal fluid (OR=1.449,95%CI 1.063-1.975) were the factors affecting postoperative gastrointestinal function recovery (P<0.05). Conclusion The elderly patients with gastrointestinal tumors are more prone to delayed recovery of gastrointestinal function after surgery. Patients with high body mass index, low preoperative albumin, intraoperative massive bleeding and abdominal fluid are high-risk groups for gastrointestinal dysfunction, and targeted intervention is needed to promote rapid recovery of gastrointestinal function after surgery.

Abstract:Objective To investigate the effect of immediate hemodilution following venoarterial extracorporeal membrane oxygenation(VA-ECMO) initiation on organ function and treatment strategies in cardiac patients. Methods We retrospectively analyzed the clinical data of 50 patients who received VA-ECMO in the Cardiology Department of First Medical Center of Chinese PLA General Hospital between January 2019 and January 2023. According to the decrease in hematocrit (Hct) after VA-ECMO initiation, the patients were divided into the Hct decrease ≥ 30% (Hct^Δ30%+) group (n=17) and the Hct decrease < 30% (Hct^Δ30%-) group (n=33). The two groups were compared in their biomarkers of organ function, blood transfusion, intra-aortic balloon pump (IABP), and continuous renal replacement therapy (CRRT). SPSS statistics 25.0 was used for data analysis. Based on the data type, t test, Mann-Whitney U test, Chi-square test, or Fisher′s exact test was used for inter-group comparisons. Results The proportion of patients aged 65 and over was with 52.9% (9/17) in Hct^Δ30%+group and 36.4% (12/33) in the Hct^Δ30%-group. There was no statistically significant difference between the two groups in the general clinical characteristics and clinical indicators before VA-ECMO initiation (P>0.05). After VA-ECMO initiation, the Hct^Δ30%+ group had greater peaks than the Hct^Δ30%- group in creatine kinase-myocardial band (CK-MB), aspartic transaminase, and alanine transaminase with statistically significant differences (P<0.05 for all). Compared with Hct^Δ30%- group, Hct^Δ30%+ group were more likely to receive treatment of IABP (70.6% vs 36.4%) and CRRT (64.7% vs 18.2%), and had higher dose of transfusion of red cell suspensions and plasma (P<0.05 for all). Conclusion Patients with a Hct decrease≥ 30% after VA-ECMO initiation required greater volume of blood transfusion, was associated with more severe organ damage, and had a higher proportion of those who used adjunct IABP or CRRT. A Hct decrease ≥ 30% after VA-ECMO initiation can serve as a new clinical indicator, providing an important reference for selecting treatment strategies and improving prognosis.

Abstract:Objective To investigate the status quo of delayed intravenous thrombolysis (IVT) decision making and related influencing factors in elderly patients with acute cerebral infarction (ACI). Methods Clinical data of 291 elderly ACI patients receiving IVT in our hospital from April 2021 to April 2023 were collected and retrospectively analyzed. The reasons of delayed decision for IVT were analyzed, and the delayed decision time was compared in the patients with different clinical characteristics. Multivariate logistic regression analysis was used to analyze the risk factors of delayed IVT decision in elderly ACI patients. SPSS statistics 22.0 was employed for statistical analysis. Independent sample t test was utilized for comparison between two groups, one-way analysis of variance for comparison among multiple groups, and LSD-t test for pairwise comparisons. Results In the 291 elderly ACI patients, the main reason for delayed decision making was lack of disease-related knowledge, accounting for 40.55% (118/291), and the decision time of IVT was (34.28±10.40) min for these patients and their families. The results of univariate analysis showed that there were no significant differences in gender, time from onset to admission, monthly family income, awareness of ACI occurrence, first onset, severity of symptoms, and intravenous thrombolytic therapy between two groups, but significant differences were observed in age, decision-makers, whether they had received the relevant knowledge of disease, whether they paid attention to the risk factors of disease and active prevention for ACI in the elderly (P<0.05). Multivariate logistic regression analysis indicated that age ≥70 years old (OR=3.420, 95%CI 1.273-9.188; P=0.015), patients and their families as decision makers (OR=1.244, 95%CI 1.037-1.492; P=0.019), not receiving disease-related knowledge in the past (OR=4.579, 95%CI 1.507-13.913; P=0.007), no attention to the risk factors of disease occurrence and active prevention (OR=2.333, 95%CI 1.148-4.741; P=0.019) were risk factors for delayed IVT decision in elderly ACI patients. Conclusion The delayed decision of IVT therapy in elderly ACI patients is affected by many factors. Clinical identification and corresponding intervention should be taken in combination with relevant factors.

Abstract:Objective To investigate the diagnostic value of serum soluble CD40 ligand (sCD40L) and matrix metalloproteinase-9 (MMP-9) in carotid plaque instability in the elderly patients with cerebral ischemic stroke (CIS). Methods A retrospective analysis was made of the clinical data of 266 elderly (≥60 years old) CIS patients (CIS group) admitted to Yantai Penglai Hospital of Traditional Chinese Medicine from August 2021 to December 2022 and 234 healthy volunteers who underwent physical examination in the same hospital during the same period (control group). The two groups were compared in serum sCD40L and MMP-9 levels to analyze their value in the early diagnosis of CIS. According to the carotid plaque status, the CIS group was divided into a plaque stable group (n=106) and a plaque unstable group (n=160). The factors affecting plaque instability in the elderly CIS patients were analyzed, and the diagnostic value of serum sCD40L and MMP-9 levels in the carotid plaque instability among them was investigated. SPSS statistics 20.0 was used to analyze the data. Depending on the data type, t test orχ² test was used for comparison between groups. Multivariate logistic regression was used to analyze the factors affecting carotid plaque instability in the elderly CIS patients, and the ROC curve was used to analyze the diagnostic efficacy of serological indicators in carotid plaque instability in them. Results The serum levels of sCD40L and MMP-9 in the CIS group were significantly higher than those in control group with statistically significant difference (P<0.05). All patients in the control group were plaque free, and in the CIS group, 106 patients had stable plaques and 160 patients unstable plaques. In comparison, the plaque unstable group and the plaque stable group showed statistically significant differences in the levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), sCD40L, MMP-9, fibrinogen (FIB) and white blood cell count (WBC) (t=13.008,9.511,14.514,20.972,13.252,16.344,10.232; P<0.05). Multivariate logistic regression analysis showed that TC (OR=1.758,95%CI 1.083-2.852), LDL-C (OR=2.275,95%CI 1.045-4.954), sCD40L (OR=1.956, 95%CI 1.112-3.440), and MMP-9 (OR=1.846,95%CI 1.151-2.961) were independent risk factors of carotid plaque instability in CIS patients (P<0.05). The area under the curve (AUC) of serum sCD40L and MMP-9 for carotid artery unstable plaque diagnosis in elderly CIA patients was 0.967 and 0.939, respectively. Conclusion TC, LDL-C, sCD40L and MMP-9 are independent risk factors for carotid plaque instability in CIS patients, and clinical monitoring of these indicators should be strengthened. In addition, the monitoring of serum sCD40L and MMP-9 levels can provide an objective basis for the early diagnosis of CIA and the assessment of carotid plaque instability in CIA patients.

Abstract:Objective To explore the occurrence of metabolic syndrome (MS) in elderly patients with hypertension in Urumqi region, Xinjiang, and investigate their quality of life and its related influencing factors. Methods A total of 1 566 elderly patients with hypertension admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2021 to July 2022 were enrolled in the study. The occurrence of MS was investigated, and the status quo of quality of life was investigated with 36-item short-form health survey (SF-36). According to occurrence of MS or not, the patients were divided into MS group (n=854) and non-MS group (n=712), and the SF-36 score was compared between the two groups. The patients were also assigned into excellent group (n=669) and moderate-poor group (n=897) according to their SF-36 score. SPSS statistics 19.0 was used for data processing. Based on different data type, Chi-square test or rank sum test was employed for intergroup comparison. Multivariate logistic regression model was applied to analyze the influencing factors for quality of life in elderly patients with hypertension. Results Among the 1 566 elderly patients with hypertension, 54.53% (854/1 566) were diagnosed with MS, and 42.72% (669/1 566) had excellent overall quality of life, and 57.28% (897/1 566) had moderate-poor quality of life. The quality of life was significantly lower in the MS group than the non-MS group (P<0.05). Multivariate logistic regression analysis indicated that living alone (OR=2.323,95%CI 1.642-3.287), multiple medication (OR=2.568,95%CI 1.558-4.233) and comorbidity of ≥3 chronic diseases (OR=2.568,95%CI 1.558-4.233) were the risk factors affecting the quality of life in elderly patients with hypertension, and the frequency of going out (OR=0.257,95%CI 0.109-0.604) and physical exercise (OR=0.176,95%CI 0.062-0.499) were the protective factors of quality of life. Conclusion The overall quality of life in elderly hypertension patients in Urumqi region, Xinjiang is not good, and it is necessary to pay more attention to those living alone and those complicated with ≥3 types of chronic diseases. Clinicians should timely adjust the drug dosage and regimen for multiple drug users, and encourage the patients to increase the social activities and physical exercise. In addition, MS is quite common in hypertension patients in this region, and its complication will further reduce their quality of life, thus in clinical practice, prevention and control of MS is necessary.

Abstract:Objective To analyze the factors influencing compliance with lifestyle intervention in the elderly patients with newly-diagnosed type 2 diabetes mellitus (T2DM). Methods A retrospective analysis was made of the clinical data of 86 elderly patients with newly-diagnosed T2DM admitted to Haikou Hospital Affiliated to Xiangya School of Medicine, Central South University, from January to June 2022. Their compliance with lifestyle intervention was assessed at follow-up visits 6 months later. The patients were divided into poor compliance group (n=41) and good compliance group (n=45). The two groups were compared in demographic characteristics, homeostasis model assessment-insulin resistance (HOMA-IR) and homeostasis model assessment-islet β cell function index (HOMA-β). SPSS statistics 23.0 was employed to process and analyze the data. According to the data type, t test,χ² test or continuous correctedχ² test was used for comparison between groups. Binary logistic regression analysis was used to analyze the factors influencing compliance with lifestyle intervention in the elderly patients with newly-diagnosed T2DM. Results HOMA-IR in both groups at follow-up visits was reduced compared with that at the first visit (P<0.05), and HOMA-IR in the good compliance group was lower than that in the poor compliance group (P<0.05). HOMA-β in both groups was enhanced compared with that at the first visit (P<0.05), and HOMA-β in the good compliance group was higher than that in the poor compliance group (P<0.05). Binary logistic regression analysis showed that divorced/widowed (OR=2.633,95%CI 1.513-4.581; P<0.05), living alone (OR=2.326,95%CI 1.218-4.442; P<0.05), and having a family history of diabetes mellitus (OR=0.655,95%CI 0.197-0.983; P<0.05) were contributing factors of poor compliance with lifestyle intervention in the elderly T2DM patients. Conclusion Among the elderly patients with newly-diagnosed T2DM, those with poor compliance with lifestyle intervention have poor islet β cell function and insulin resistance control, the divorced/widowed and the solitary are more likely to have a poor compliance with lifestyle intervention, and those with a family history of diabetes mellitus often have a good compliance.

Abstract:Objective To explore the related influencing factors of rehabilitation training compliance in elderly patients with hemiplegia after acute stroke. Methods Clinical data of 149 elderly patients with acute post-stroke hemiplegia admitted to our hospital from April 2021 to April 2023 were collected and retrospectively analyzed. Rehabilitation exercise compliance scale was used to evaluate their compliance, and the scores of physical exercise compliance, exercise monitoring compliance and proactively seeking advices on compliance were compared among the patients with different clinical characteristics. SPSS statistics 22.0 was employed for data analysis. Depending on the data type, student′s t test or ANOVA was applied for inter-group comparison. Multivariate logistic regression analysis was conducted to analyze the influencing factors of the compliance in these elderly patients. Results For the 149 elderly patients with acute post-stroke hemiplegia, the score of physical exercise compliance, exercise monitoring compliance and proactively seeking advice on compliance was (20.19±5.15), (7.21±2.88), and (7.42±2.64) points, respectively. Significant difference was observed in the physical exercise compliance score among the patients with different education level, marital status, family monthly income, severity of neurological deficit and anxiety or depression (P<0.05), so was in the score of exercise monitorin compliance among the patients with different education levels and anxiety or depression (P<0.05), and in the score to proactively seeking advice on compliance in the patients with different education level, marital status and being anxious or depressed (P<0.05). Multivariate logistic regression analysis showed that education level at junior high school (OR=2.469,95%CI 1.244-4.900), divorced or widowed or unmarried (OR=3.109,95%CI 1.437-6.726), monthly family income <2 000 yuan/month (OR=2.436,95%CI 1.228-4.832), anxiety or depression (OR=1.346,95%CI 1.038-1.745), and severe neurological deficit (OR=3.775,95%CI 1.841-7.741) were the risk factors for compliance to physical exercise. Education level of junior high school (OR=1.190,95%CI 1.006-1.408) and anxiety or depression (OR=1.438,95%CI 1.118-1.850) were the risk factors for patients′ compliance to exercise monitoring. Education level of junior high school (OR=3.987, 95%CI 1.419-11.202), divorce or widowed or unmarried (OR=3.883,95%CI 1.502-10.038), and anxiety or depression (OR=1.927,95%CI 1.333-2.786) were risk factor for compliance to proactively seeking advice. Conclusion The rehabilitation training compliance in elderly patients with acute post-stroke hemiplegia is affected by many factors, such as education level, marital status, family monthly income, anxiety or depression, and severity of neurological deficit, and all of these factors should be paid attention to by clinicians.

Abstract:Objective To analyze the relationship between disease uncertainty, social support and quality of life in the elderly patients with coronary heart disease. Methods A retrospectively analysis was made of the clinical data of 150 elderly patients with coronary heart disease in the Department of Cardiology of First Affiliated Hospital of Xinjiang Medical University from April 2022 to March 2023, including general demographic data, Mishel uncertainty in illness scale (MUIS), social support scale and quality-of-life scale scores. SPSS statistics 26.0 was used for data analysis. Measurement data were compared using independent sample t test or analysis of variance. Pearson correlation was used to analyze the correlation between disease uncertainty, social support and quality of life in the elderly patients with coronary heart disease, and logistic regression was used to analyze the influencing factors of quality of life in the elderly patients with coronary heart disease. Results The 150 elderly patients with coronary heart disease scored (119.76±12.85) points for disease uncertainty, (61.83±5.42) points for social support, and (63.91±6.28) points for quality of life. There were significant differences in the quality-of-life scores of elderly patients with coronary heart disease in the aspects of education level, per capita monthly family income and treatment payment method (P<0.05). The quality of life was negatively correlatied with disease uncertainty score (r=-0.501; P<0.05), and positively with social support score (r=0.457; P<0.05). Education level (OR=2.824,95%CI 1.343-5.935), household monthly income per capita (OR=2.751,95%CI 1.345-5.626), treatment payment method (OR=2.702, 95%CI 1.379-5.292), disease uncertainty (OR=3.111,95%CI 1.474-6.565), and social support (OR=2.933,95%CI 1.451-5.928) were the influencing factors of quality of life in the elderly patients with coronary heart disease. Conclusion The quality of life of elderly patients with coronary heart disease is low and is related to disease uncertainty and social support. Interventions can betargeted at the influencing factors of quality of life of the elderly patients with coronary heart disease to improve their quality of life.

Abstract:Due to the high prevalence and fatality rate, heart failure has always been a major medical problem affecting the health of Chinese people. Heart failure often causes dysfunction of other organs, increasing the difficulty of diagnosis and treatment. Complicated with dysfunction of other organs, the prognosis of patients is worse than that of those with simple heart failure. In heart failure, decreased cardiac output and venous congestion lead to cardiac hepatic fibrosis. Studies have shown that heart failure patients with hepatic fibrosis have a higher mortality rate, suggesting a poor prognosis in them. Some scholars claim that liver fibrosis is related to the prognosis of heart failure and that some indexes of hepatic fibrosis have shown prognostic value for heart failure. This article reviews the indexes of hepatic fibrosis.

Abstract:Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory diseases, characterized by chronic respiratory symptoms (dyspnea, cough, sputum, acute exacerbation).Infection is the main reason for the deterioration of COPD and the decline of lung function. Respiratory microecology and its immunomodulatory function play an important role in it.The new generation of gene sequencing technology allows a clearer understanding of the composition of respiratory microecology and its correlation with respiratory diseases. It not only reveals that there is a rich microbial community in the lungs of healthy people, but also that the airway microecological structure and the relative abundance of each bacterial community have changed in COPD patients compared with healthy people.This article reviews the research progress of airway microbiota in COPD.

Abstract:Mitochondria, our body′s energy factory, have their own separate genome — mitochondrial DNA (mtDNA). Normal energy supply of mitochondria is of great importance to myocardium, a high energy consuming tissue, while mtDNA can affect the energy supply of mitochondria to a certain extent. According to the latest Global Burden of Disease study, cardiovascular disease (CVD) is the top cause of death, and coronary heart disease (CHD) is one of the leading causes of death for CVD patients. As a newly discovered biomarker, mtDNA has a strong correlation with the pathogenesis, potential therapeutic targets and prognosis of CHD. In this article, we review the research progress of the correlation between mtDNA and CHD.

Abstract:With the deepening of aging population in China, frailty, as a common geriatric syndrome, has become a new prominent problem in public health. Heart failure and frailty often coexist in the elderly, leading to a variety of adverse clinical outcomes. It is of vital importance of profoundly investigating the pathogenesis, summarizing the influencing factors, and exploring effective intervention measures so as to improve the quality of life and prognosis of these patients. Therefore, in this article, we elucidate the pathophysiological mechanism and influencing factors based on relevant research progress, and review the intervention measures, so as to provide a reference for the development of intervention programs for elderly people with heart failure and frailty.