Abstract:Objective To investigate physical activity insufficiency and sedentary behavior in the elderly stroke patients, and to analyze the influencing factors of insufficient activities. Methods From January to October 2022,302 elderly stroke patients in a tertiary hospital were selected and investigated using general information, disease status, International Physical Activity Questionnaire, International Fall Efficacy Scale, geriatric depression scale-15, timed up and go test. According to the physical activity level, the patients were divided into two groups, and they were compared for the differences in the indicators. SPSS 26.0 was used for data analysis. Comparison between the two groups was performed using t-test or χ²test depending on the data type. Binary logistic regression was used to analyze the independent influencing factors of physical activity insufficiency. Results Among the 302 elderly stroke patients, 115 (38.1%) had inactive physical activity , 225 (74.5%) had sedentary behavior, 124 (41.10%) had fear of falling, 55 (18.21%) had depression, and 212 (70.20%) had impaired mobility. Univariate analysis showed that there were statistically significant differences in age, marital status, polypharmacy, hypertension, diabetes, depression, lower extremities paresthesias, use of walkers, fear of falling, sedentary behavior, and impaired mobility (P＜0.05). Multivariate logistic regression analysis showed that fear of falling (OR=4.66, 95%CI 2.64-8.24), sedentary behavior (OR=4.03,95%CI 1.67-9.74), paresthesia of the lower extremities (OR=2.23,95%CI 1.15-4.33), and depression (OR=2.21,95%CI 1.08-4.53) were independent risk factors of insufficient activities in the elderly stroke patients (P<0.05). Conclusion The elderly stroke patients are mostly physically inactive and sedentary. To address their inactivity, it is not only necessary to improve their physical function, to strengthen lower limb muscles, and to avoid being sedentary by intermittent and mild physical activities, but also necessary to attend their psychological problems. A multi-dimensional intervention program should be formulated to enhance activity for more effective recovery.

Abstract:Objective To investigate the risk factors of long-term in-stent restenosis (ISR) and its correlation with remnant cholesterol (RC) in coronary heart disease (CHD) with low-density lipoprotein cholesterol (LDL-C) compliance after percutaneous coronary intervention (PCI). Methods A retrospective study was conducted of the clinical data of 239 CHD inpatients in the Department of Cardiology of Yixing People′s Hospital from January 2015 to October 2022. All patients had a previous stent placement and underwent coronary angiography after hospitalization. Fasting blood routine and biochemical indicators were tested on the day following admission. According to the results of coronary angiography, they were divided into ISR group (n=58) and non-ISR group (n=181). SPSS statistics 16.0 was used for data analysis. According to the data types, t test or Chi-square test was used for intergroup comparison. The Spearman correlation was used to analyze the correlation between RC and ISR. Receiver operating characteristic (ROC) curve was drawn to determine the optimal cutoff value of RC. Multivariate logistic regression was used to analyze the risk factors of ISR. Results The two groups showed statistical significant differences in age, total cholesterol (TC), RC, number of stents, total stent length and proportion of diabetes mellitus, smoking and multiple vessel lesions (P<0.05). The RC interquartile range was calculated, and the patients were divided into four groups (Q1-Q4) accordingly with an ISR rate of 20.0%, 14.8%, 22.0%, and 40.7%, respectively, showing statistically significant differences (P<0.05). Further Spearman correlation analysis revealed a positive correlation between RC and ISR (r=0.179; P<0.05). ROC analysis showed an area under ROC curve of 0.636 (95% CI 0.572-0.697; P<0.05) for RC. By calculating the Youden index, the optimal cutoff value for RC was 0.47 mmol/L with a sensitivity of 51.72% and a specificity of 75.14%. Multivariate logistic regression analysis showed that age (OR=1.041,95%CI 1.005-1.078; P＜0.05), smoking (OR=5.797, 95%CI 1.617-20.774; P＜0.05), multiple vessel lesions (OR=3.937,95%CI 1.258-12.326; P＜0.05), total stent length (OR=1.034,95%CI 1.001-1.070; P＜0.05), and RC>0.47 mmol/L (OR=3.416, 95%CI 1.535-7.602; P＜0.05) were risk factors of ISR. Conclusion There is a positive correlation between RC and ISR in CHD patients with LDL-C compliance after PCI, and RC is an independent risk factor of ISR after PCI.

Abstract:Objective To investigate frailty in the elderly inpatients with chronic obstructive pulmonary disease (COPD) and to analyze its influencing factors. Methods A total of 260 elderly COPD inpatients in China Resources WISCO General Hospital from January 2021 to December 2022 were selected by convenience sampling. A self-made questionnaire was used to gather patients′ general information. The patient′s frailty was assessed using the Clinical Frailty Scale. Hemoglobin, 25-hydroxyvitamin D (25-OH-D), interleukin-6 (IL-6) were measured. Univariate and multivariate logistic regression analysis were performed to analyze the influencing factors of frailty in the elderly COPD inpatients. SPSS statistics 25.0 was used for statistical analysis. Data comparison between two groups was perfomed using t test or χ² test depending on data type.Results A total of 260 questionnaires were distributed and 260 (100.00%) were recovered. Among the 260 patients, 67 (25.77%) developed frailty. Gender, age, smoking, exercise habits, nutritional status, disease severity and lung function were the influencing factors for frailty in the elderly COPD inpatients (P<0.05). The levels of hemoglobin and 25-OH-D in the frailty group were significantly lower than those in the non-frailty group, the levels of IL-6 in the frailty group were significantly higher than those in the frail group, and the differences were statistically significant (P<0.05). Logistic regression analysis showed gender, age, smoking, exercise habits, nutritional status, disease severity, lung function, low hemoglobin expression, low 25-OH-D expression, and high IL-6 expression were risk factors for frailty in the elderly COPD inpatients (OR＝3.174,1.556,3.162,1.735,2.649,5.089,2.162,1.314,1.974,2.173; P<0.05). Conclusion The incidence of frailty among the elderly COPD inpatients in the hospital in Wuhan is high and is affected by gender, age, smoking, exercise habits, nutritional status, disease severity, lung function, hemoglobin, 25-OH-D, and IL-6 levels. Reasonable clinical intervention should be offered to reduce the incidence of frailty.

Abstract:Objective To analyze the factors affecting urinary control recovery in the elderly patients with prostate cancer after radical prostatectomy. Methods A total of 131 elderly prostate cancer patients who underwent radical prostatectomy were selected as the observation subjects. They were divided into urinary incontinence group (n=46) and urinary control group (n=85) based on the postoperative recovery of urinary control. The two groups were compared in clinical data and perioperative indicators. Multiple logistic regression analysis was used to analyze the factors affecting the patients′ postoperative recovery of urinary control after radical prostatectomy. SPSS 20.0 was used for data analysis. Data comparison between two groups was performed usingχ² test. Results The proportion of patients aged≥75 years, body mass index (BMI)≥24 kg/m², previous transurethral resection of prostate (TURP), history of hypertension and history of diabetes in the urinary incontinence group were significantly higher than those in the urinary control group, the differences being statistically significant (P<0.05). The proportion of preoperative prostate volume of 30-75 ml, tumor stage≥T3a, and intraoperative bleeding≥600 ml in the urinary incontinence group were significantly higher than those in the urinary control group, but the proportion of the maximum urethral length preservation (MULP), preserved neurovascular bundle (NVB), complete preservation of bladder neck, and regular anal lifting training after surgery were significantly lower than those in the urinary control group, the differences being statistically significant (P<0.05). Age≥75 years, previous TURP history, tumor stage≥T3a, and intraoperative bleeding volume≥600 ml were all risk factors for urinary incontinence after radical prostatectomy (OR=2.451,3.015,2.156,3.074; P<0.05); MULP, preserved NVB, complete preservation of bladder neck, and regular anal lifting training after surgery were protective factors for urinary incontinence after radical prostatectomy (OR=0.674,0.845,0.874,0.912; P<0.05). Conclusion Various factors affect the recovery of urinary incontinence in the patients after radical prostatectomy, among which age, previous TURP history, tumor staging, and intraoperative bleeding are all risk factors for urinary incontinence after radical prostatectomy. Early intervention in the patients with high-risk factors of postoperative urinary incontinence can help reduce the incidence of urinary incontinence.

Abstract:Objective To investigate the role of coronary artery computed tomography angiography (CCTA) in identifying the plaque characteristics and prognosis in the elderly patients with acute coronary syndrome (ACS). Methods A retrospective analysis was made of the clinical data of 208 elderly patients with suspected coronary heart disease (CHD) admitted to the Chest Pain Center of Qionghai People′s Hospital of Hainan Province from February 2021 to December 2022. Among them, 58 ACS patients were included in the ACS group. According to their gender, age and cardiovascular risk factors (smoking history, hypertension, diabetes, blood lipid levels, etc.), another 58 patients with stable angina pectoris (SAP) were selected as a SAP group using the propensity score matching method (1∶1 ratio) during the same period. All patients underwent CCTA examination, and the two groups were compared in plaque characteristic indexes such as plaque length, calcified plaque (CP) volume, non-calcified plaque (NCP) volume, total plaque volume, CP load, NCP load, and total plaque load. In addition, 58 ACS patients were divided into major adverse cardiovascular events (MACEs) group (n=15) and non-MACEs group (n=43) based on prognosis. Patients with different prognosis were compared in the plaque characteristic indexes on CCTA. SPSS statistics 22.0 was used for data analysis. Depending on the data type, t test orχ² test was used for comparison between groups. Pearson analysis was performed for the correlation between blood lipid levels and plaque characteristic indexes. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of each plaque characteristic index on ACS and MACEs. Results Plaque length, NCP volume, and NCP load in the ACS group were significantly higher than those in the SAP group, with statistically significant differences (P<0.05). The MACEs group had significantly higher plaque length, NCP volume, and NCP load than the non-MACEs group, with statistically significant differences (P<0.05). Pearson correlation analysis showed that serum low-density lipoprotein cholesterol (LDL-C) was positively correlated with plaque length (r=0.463), CP volume (r=0.246), NCP volume (r=0.414), total plaque volume (r=0.292), CP load (r=0.251), NCP load (r=0.392), and total plaque load (r=0.215; all P<0.05). The ROC curve analysis showed that patch length, NCP volume and NCP load had good predictive value for ACS with area under the curve (AUC) of 0.843 (95%CI 0.761-0.925), 0.814 (95%CI 0.703-0.926) and 0.721 (95%CI 0.573-0.869); optimum cutoff value of 19.19 mm, 152.99 mm³ and 42.56%; sensitivity of 91.67%, 91.67% and 66.67%, and specificity of 75.00%, 63.54% and 77.08%, respectively (P<0.05). Patch length, NCP volume, and NCP load demonstrated good predictive value for MACEs, with AUC of 0.694 (95%CI 0.515-0.876), 0.711 (95%CI 0.502-0.920) and 0.735 (95%CI 0.551-0.919); optimum cutoff value of 21.02 mm, 169.62 mm³ and 45.37%; sensitivity of 77.78%, 66.67% and 88.89%, and specificity of 59.18%, 85.71% and 61.22% (P<0.05). Conclusion The plaque characteristic indexes on CCTA not only have good diagnostic value but also can effectively predict the occurrence of MACEs in the elderly ACS patients within one year.

Abstract:Objective To explore the effect of platelet distribution width (PDW) on the risk of diabetic peripheral neuropathy (DPN) in patients with newly diagnosed type 2 diabetes mellitus (T2DM). Methods A retrospective study was conducted on 1001 newly diagnosed T2DM patients admitted to the Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University from January 2017 to December 2021. General data, platelet-related indexes and biochemical indexes were collected. They were divided into DPN group (n=481) and non-DPN group (n=520). EmpowerStats and R3.4.3 for Windows were used for statistical analysis. Student′s t test, Mann-Whitney U test or Chi-square test was used for data comparison between two groups. Pearson correlation analysis was performed to evaluate the correlation between PDW and biochemical indexes, logistic regression analysis to analyze whether PDW was an independent factor for DPN risk, and multiple linear regression analysis to determine whether PDW was an independent factor of nerve conduction velocity. Results The PDW value was significantly higher in the DPN group than the non-DPN group [(14.58±2.26) vs (14.20±2.41) fl; P=0.01]. After adjusted for general data, platelet-related indexes and biochemical indexes, multivariate regression analysis showed that PDW was an independent risk factor for DPN, with the risk of DPN increasing by 11% per unit increment of PDW value (OR=1.11; P<0.05) and by 29% per standard deviation increment of the value (OR=1.29; P<0.05). Compared with the first quartile, PDW indicated a significantly increased risk of DPN at the third (OR=2.43; P=0.01) and fourth (OR=2.01; P<0.05) quartiles. Multiple linear regression analysis using DPN as a quantitative indicator suggested that PDW was an independent risk factor for nerve conduction velocity. Conclusion In newly diagnosed T2DM patients, PDW value is significantly higher in those complicated with DPN than those without, and it is an independent risk factor for DPN.

Abstract:Objective To observe the characteristics of ambulatory blood pressure in elderly patients with hypertension and explore the factors affecting the circadian rhythm of blood pressure in them. Methods A retrospective study was conducted of the clinical data of a total of 296 eligible elderly hypertensive patients (aged ≥60 years) treated at the Hypertension Clinic of Shanxi Bethune Hospital from January to June of 2021. According to the circadian rhythm of blood pressure, they were divided into a dipper group (n=56), a non-dipper group(n=134), and a reverse dipper group (n=106). The data collected included the general clinical information of the patients, 24 h ambulatory blood pressure monitoring, arteriosclerosis monitoring, 24 h urine electrolytes, and 24 h urine microalbumin detection. SPSS statistics 26.0 was used for data analysis. According to the data type, one-way ANOVA, Kruskal-Wallis H test orχ² test was used to compare the groups. Binary logistic regression was performed to analyze the factors influencing the circadian rhythm of blood pressure. Results Abnormal circadian rhythm of blood pressure (non-dipper group and reverse dipper group) was found in 81.1% of the elderly hypertensive patients, which was significantly higher than that of the normal blood pressure rhythm group (dipper group). The age of the dipper group was lower than that of the non-dipper group and the reverse dipper group [68.00 (65.00,70.00) vs 70.00 (68.00,73.00), 71.00 (69.00,74.00) years], and the differences were statistically significant (P<0.05). The proportion of smokers in the dipper group was lower than that in non-dipper group and reverse dipper group(7.1% vs 39.6%, 47.2%), and the differences were statistically significant (P<0.05). The nocturnal blood pressure drop rate in the dipper group, non-dipper group and reverse dipper group decreased gradually [12.40% (10.70%,14.78%),3.70% (1.58%,5.83%),-4.50% (-8.00%, -2.30%)], and there were significant differences among all groups (P<0.05). The right brachial-ankle pulse wave velocity (baPWV) in the reverse dipper group was significantly higher than that in the non-dipper group and the dipper group[(1 851.57±215.87) vs (1 747.81±244.65), (1 687.00±201.61)cm/s]; the left baPWV in the reverse dipper group was higher than that in the non-dipper group and the dipper group [(1 869.13±232.15) vs (1 758.57±259.18), (1 692.25±205.34) cm/s]; the differences were statistically significant (P<0.05). The 24 h urinary sodium in the reverse dipper group was lower than that in the dipper group[83.00 (59.00,114.75) vs 102.50 (84.00,126.75) mmol/24h]; the 24 h urine microalbumin in the reverse dipper group was higher than that in the dipper group[48.25(36.33,61.64) vs 41.09(32.00,48.94) mg/24h]; the difference was statistically significant (P<0.05). Binary logistic regression analysis showed that age (OR=1.328,95%CI 1.178-1.496; P<0.001) and smoking history (OR=14.953,95%CI 4.706-47.511; P<0.001) were independent risk factors, and 24 h urinary sodium (OR=0.988,95%CI 0.979-0.998; P=0.021) was an independent protective factor of the circadian rhythm of blood pressure in elderly hypertensive patients. Conclusion The incidence of abnormal circadian rhythm of blood pressure significantly increase in the elderly hypertensive patients. Age and smoking history are independent risk factors, and 24 h urine sodium was an independent protective factor of the circadian rhythm of blood pressure in elderly hypertensive patients.

Abstract:Objective To assess the frailty status in elderly patients with non-operative stage Ⅲ epidermal growth factor receptor (EGFR) mutation-positive non-squamous non-small cell lung cancer (NSCLC) who were treated with sequential chemoradiotherapy followed by osimertinib treatment, and in those with stage Ⅳ NSCLC who were treated with stereotactic body radiotherapy (SBRT) combined with osimertinib, and analyze the influencing factors. Methods A retrospective analysis was conducted on 238 elderly patients with stage Ⅲ-Ⅳ EGFR mutation-positive non-squamous NSCLC admitted to the Shanxi Province Cancer Hospital from June 2020 to December 2021. After 3 continuous months of targeted osimertinib maintenance therapy, Numerical Rating Scale (NRS) score, Caprini risk assessment model for venous thromboembolism (Caprini) score, patient health questionnaire-9 (PHQ-9) score, geriatric 8 (G8) score were applied to these participants. According to their G8 score, they were divided into frail group(n=197) and non-frail group (n=41). SPSS statistics 19.0 was used to perform the statistical analysis. Student′s t test, Chi-square test, or Fisher exact test was employed for intergroup comparison depending on data type. And the related risk factors were identified by logistic regression analysis. Results The frailty group had higher proportion of advanced age, risk of high Caprini score and above, comorbidity; lower proportion of venous thromboembolism (VTE); higher depression level, NRS score and serum cystatin C level, but lower G8 score when compared with the non-frail group (all P<0.05). Logistic regression analysis indicated that age (OR=1.395,95%CI 1.133-1.717), depression level (OR=1.525,95%CI 1.290-1.803), NRS score (OR=7.908,95%CI 2.301-27.181), comorbidity (OR=5.490,95%CI 1.181-25.522), VTE (OR=7.530,95%CI 1.022-55.501), and serum cystatin C level (OR=1.215,95%CI 1.084-1.361) were risk factors for frailty status in the elderly patients with non-operative stage Ⅲ-Ⅳ EGFR mutation-positive non-squamous NSCLC. Conclusion Frailty is quite common among the elderly patients with non-operative stage Ⅲ-Ⅳ EGFR mutation-positive non-squamous NSCLC. They are characterized with kidney injury, and geriatric syndrome, such as nutrient loss, pain, impaired physical activity and cognitive ability, negative emotion and comorbidities. It is of great significance for early and rapidly identifying the influencing factors and implementing effective rehabilitation and treatment measures for these patients.

Abstract:Objective To investigate the influencing factors of contralateral central lymph node (Cont-CLNs) metastasis in patients with unilateral papillary thyroid carcinoma (PTC) with ipsilateral cervical lymph node metastasis (LLNM). Methods A total of 127 LLNM-PTC patients admitted to Jiangyuan Hospital Affiliated to Jiangsu Institute of Atomic Medicine from July 2018 to July 2022 were selected and divided into metastasis group (n=68) and non-metastasis group (n=59) according to whether they had Cont-CLNs metastasis. Data of the patients were collected, including gender, age, tumor size, tumor echo, blood flow signal, microcalcification, tumor number, pathological gland lobe, nodular thyroid cyst, capsule invasion, Hashimoto′s thyroiditis, incidence of central lymph node, pretracheal lymph node and prelaryngeal lymph node metastasis and postoperative complications. Binary logistic regression model was used to analyze the factors influencing the occurrence of Cont-CLNs metastasis in LLNM-PTC patients. SPSS statistics 20.0 was used for statistical analysis. Data comparison between two groups was perfomed using t test or χ² test depending on data type.Results In the metastasis group, the proportion of male, microcalcification, multiple tumor and capsule invasion was 75.00% (51/68), 47.06% (32/68), 55.88% (38/68) and 47.06% (32/68), respectively. It was higher than that in the non-metastasis group 37.29% (22/59), 16.95% (10/59), 18.64% (11/59), 15.25% (9/59), and the maximum tumor diameter in the metastat group was greater than that in the non-metastasis group (P<0.05). The metastasis rates of central lymph nodes, pretracheal lymph nodes and prelaryngeal lymph nodes were 51.47% (35/68), 44.12% (30/68) and 50.00% (34/68), respectively. It was higher than 20.34% (12/59), 15.25% (9/59) and 16.95% (10/59) in non-metastasis group (P<0.05). Binary logistic regression analysis showed that male, tumor size, microcalcification, multiple tumors, capsule invasion, central lymph node metastasis on the affected side, pretractal lymph node metastasis, and prelaryngeal lymph node metastasis were independent risk factors for Cont-CLNs metastasis, and the difference was statistically significant(P<0.05). Conclusion The occurrence of Cont-CLNs metastasis in LLNM-PTC patients is affected by multiple factors, including gender, tumor size, microcalcification, tumor number, capsule invasion, and lymph node metastasis in the central region of the affected side, pretracheal and prelaryngeal area, which deserves attention clinically.

Abstract:Objective To investigate the expression of human follistatin-like protein 3 (FSTL3) in acute lung injury caused by different inducement in mice and its significance. Methods Mouse model of septic lung injury was established by intraperitoneal injection of lipopolysaccharide (LPS), and the model of ischemia-reperfusion (IR) injury was established by clamping the left pulmonary hilum followed by opening. The protein expression level of FSTL3 in serum and the protein and mRNA expression level of FSTL3 in lung tissue were detected at different time points of lung injury. FSTL3 neutralizing antibodies (FSTL3-NA) or FSTL3 gene knockout mice were employed to evaluate the effect of FSTL3 inhibition on lung injury in mice inflicted by 2 types of injuries. Western blotting was applied to detect the protein levels of tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), superoxide dismutase (SOD) 1 and SOD2 in the lung tissues. Statistical software GraphPad Prism 9.2 was used to analyze the data. One-way AVOVA was used to compare the measurement data between groups, and student′s t test was performed for intergroup comparison. Results The serum protein level of FSTL3 was increased significantly in the mice at 12 h after intraperitoneal injection of LPS, reached a peak at 18 h, and then stabilized, both of which were significantly higher than 0 h (P<0.05). After 2 h ischemia and 2 h reperfusion, the serum protein level of FSTL3 was elevated significantly, summited at 6 h of reperfusion, and the protein level after 8 h reperfusion was still notably higher than that at 0 h (P<0.05). Western blotting and RT-PCR showed that the protein and mRNA levels of FSTL3 in the lung tissues reached the peaks after 18 h of LPS stimulation (P<0.05); after 2 h of ischemia and 2 h of reperfusion, its protein and mRNA levels in lung tissue were increased significantly (P<0.05), and reached the peaks after 4 h reperfusion (P<0.05). FSTL3-NA treatment obviously alleviated the lung pathological injury in sepsis mice, and down-regulated the protein levels of TNF-α[(1.23±0.11) vs (2.45±0.27)]and MCP-1 [(0.34±0.02)] vs (2.23±0.04)] in the lung tissue, while up-regulated the protein levels of SOD1 [(3.05±0.16) vs (1.87±0.32)] and SOD2 [(2.45±0.19) vs (1.61±0.24)] (all P<0.05). FSTL3 gene knockout also obviously alleviated the lung pathological injury in IR injured mice, and down-regulated the protein levels of TNF-α [(1.22±0.19) vs (4.13±0.21)] and MCP-1 [(0.88±0.03) vs (3.10±0.15)] in the lung tissue and up-regulated those of SOD1 [(2.27±0.16) vs (0.41±0.06)] and SOD2 [(2.04±0.13) vs (0.19±0.05)] (all P<0.05). Conclusion After LPS or IR stimulation, FSTL3 level is significantly increased in both mouse lung tissue and serum, while its inhibition or knockout could significantly reduce inflammation and oxidative stress in murine lung tissue.

Abstract:Sleep patterns change with aging, and the elderly are prone to sleep disorders including difficulty in falling asleep, sleep fragmentation, daytime sleepiness, and early awakening. Alzheimer′s disease (AD) is an age-related neurodegenerative disease and the most common cause of dementia in the elderly. More and more studies have shown a remarkable correlation between AD and sleep disorders, especially sleep-wake disorders. They may affect the metabolism of the brain′s lymphatic system, reduce the clearance of amyloid β protein, and play a key role in the onset and progression of AD. Despite the previous studies, the causality between sleep disorders and AD as well as the underlying mechanism remains uncertain. Moreover, consensus is yet to be reached for a guidance on sleep regulation for patients with AD-related cognitive impairment. In this article, we reviewed the latest research evidence on aging and physiological changes in sleep, the correlation between sleep disorders and AD, and management strategies for sleep disorders and cognitive improvement, aiming to raise the awareness of the importance of sleep regulation for early prevention.

Abstract:Sarcopenia, the age-related loss of muscle mass and functions, increases the risk of falls, fractures, death, and hospitali-zation and poses a serious threat to the health of the elderly. The construction of animal models constitutes the basis for research in its pathogenesis, clinical intervention and treatment planning. Due to the complexity of the sarcopenia phenotype, it is crucial to select an optimal modeling method and construct a suitable animal model. In this article,we reviewed the progress in methodology in animal model construction for sarcopenia in recent years, providing reference for the research in the pathogenesis, prevention, and treatment of sarcopenia.

Abstract:Sarcopenia, a disease characterized by the gradual loss of muscle quantity, mass and strength, has become a wide concern. Sarcopenia occurs easily in the elderly patients with late-stage stroke. Stroke and sarcopenia are closely associated with pathogenesis, and the two affect mutually in the disease progression. Previous studies have found a relationship between sarcopenia and the severity of lesions, adverse functional outcomes, neurological deterioration, recurrent cerebrovascular events, and cognitive dysfunction in the elderly stroke patients. In this article, we reviewed the current research status of the influence of sarcopenia on the prognosis of the elderly stroke patients and discussed the correlation between the two, so as to provide directions for future clinical research.