Abstract:Objective To observe the effect of sacubitril/valsartan on renal function in patients with chronic heart failure (CHF) and renal insufficiency. Methods A total of 84 consecutive CHF patients with renal insufficiency who visited the First Hospital of Qinhuangdao form December 2020 to March 2022 were enrolled and divided into sacubitril/valsartan group (n=48) and control group (n=36). The sacubitril/valsartan group received sacubitril/valsartan and the control group received single valsartan. The two groups were observed for the changes in serum creatinine, estimated glomerular filtration rate (eGFR), urea nitrogen, uric acid, and worsening renal function (WRF) at 6 and 12 months after medication. SPSS statistics 22.0 was used for statistical analysis. Data comparison between two groups was perfomed using t test, non-parametric rank sum test, non-parametric test, Mann-Whitney U test or χ² test depending on data type. Results At 6 months, there were no significant differences in serum creatinine (P=0.254) and eGFR (P=0.061) in comparison with the baseline between the two groups. The decreased values of urea nitrogen [-2.62 (1.83,3.90) vs 0.45 (0.29,0.70) mmol/L; P<0.01] and uric acid [-137.00(-92.30,-201.13) vs -9.65(49.00,-79.80) μmol/L; P =0.000] were significantly higher in the sacubitril/valsartan group than those in the control group. Compared with the control group, sacubitril/valsartan reduced systolic blood pressure [(132±17) vs (133±24) mmHg (1mmHg=0.133kPa); P=0.824] and diastolic blood pressure [(81±14) vs (82±12) mmHg; P=0.732], but there was no statistical differences. NYHA classification was significantly improved between two groups (Z=-2.150; P=0.032). Compared with the baseline at, 12 months, the decline of eGFR was lower in the sacubitril/valsartan group than the control group [-2.21 (1.33,3.49) vs -22.11 (12.32,29.67) ml/(min·1.73 m²); P=0.023]; the increase in serum creatinine was significantly lower in the sacubitril/valsartan group than in the control group [1.50 (0.98,2.07) vs 31.65 (22.77,42.53) μmol/L; P=0.043]; the decreases in urea nitrogen [-2.80 (2.01,4.23) vs 0.80 (0.58,1.14) mmol/L; P<0.01] and uric acid [-141.00(-96.40,-200.25) vs -8.45(45.00,-77.70) μmol/L; P=0.011] were significantly higher in the the sacubitril/valsartan group than in the control group. The sacubitril/valsartan group had a significantly greater reduction in systolic blood pressure [(123±14) vs (130±17) mmHg; P=0.042] and diastolic blood pressure [(76±11) vs (81±11) mmHg; P=0.042] and significantly better NYHA classification (Z=-2.200; P=0.028) than the control group. There was no significant difference in the incidence of WRF [3 (6.25%) vs 7 (19.44%); P=0.132] between the two groups at 6 months, but at 12 months, the incidence of WRF in the sacubitril/valsartan group is significantly lower than that in the control group [4 (8.33%) vs 9 (25.00%); P=0.037]. Conclusion In the sacubitril/valsartan group, improvement in cardiac function precedes the effect of renal protection, and blood pressure decreases simultaneously with effect of renal protection. Compared with single valsartan, sacubitril/valsartan can delay and control the worsening of renal function in CHF patients with renal insufficiency and reduce the occurrence of WRF. The renal protective effect of sacubitril/valsartan is more significant with the prolongation of medication.

Abstract:Objective To investigate the correlation of serum ferritin (SF), transferrin saturation (TSAT) and homocysteine (Hcy) with erythropoietin (EPO) hyporesponsiveness in chronic heart failure (CHF) patients with anemia and its clinical significance. Methods A total of 252 CHF patients with anemia admitted in our hospital from April 2019 to December 2021 were enrolled and divided into low response group (n=68) and non-low response group (n=184) according to their EPO response. The relevant factors affecting EPO response were analyzed and the value of SF, TSAT and Hcy was assessed in prediction for EPO hyporesponsiveness. SPSS statistics 24.0 was used to analyze the data. Student′s t test and Chi-square test were used to for comparison between groups depending on data type. Spearman correlation analysis was applied to analyze the correlation of SF, TSAT and Hcy with New York Heart Association (NYHA) classification of cardiac function. Multivariate logistic regression model was employed to analyze the influencing factors of EPO hypo responsiveness. Receiver operating characteristic (ROC) curve was used to analyze the prediction role of SF, TSAT and Hcy for EPO hyporesponsiveness.Results Statistical difference was observed in NYHA classification between the low response group and the non-low response group (P<0.05). The low response group had significantly lower SF and TSAT levels but higher Hcy levels when compared with the non-low response group (P<0.05). SF and TSAT were negatively correlated with NYHA classification (r=-0.742, -0.751; P<0.001), and Hcy was positively correlated with the classification (r=0.800; P<0.001). NYHA class IV, hemoglobin, SF, TSAT and Hcy were factors influencing EPO hyporesponsiveness (P<0.05), and the area under the curve value of SF, TSAT and Hcy combined together for predicting EPO hyporesponsiveness was 0.909, greater than that of SF (0.733), TSAT (0.752) and Hcy (0.724) alone. Its predictive sensitivity was 94.12%, and its specificity was 71.74%.Conclusion SF, TSAT and Hcy are related to EPO hyporesponsiveness and cardiac function in CHF patients with anemia. Combined detection of the three indicators can be used as a predictor for EPO responsiveness and provide reference for clinical treatment.

Abstract:Objective To observe the effects of probiotics on the course of mild coronavirus disease 2019 (COVID-19) caused by Omicron variant. Methods A retrospective analysis was performed of the medical data of 133 COVID-19 patients admitted to the third ward of Fangcang shelter hospital located in the National Exhibition and Convention Center (Shanghai) from May 2 to May 12,2022. The patients were divided into two age cohorts:adult (18-59 years old, n=79) and elderly (≥60 years old, n=54). Each cohort was further divided into control group and probiotics group according to whether they received the adjuvant treatment of probiotics (subtilis bifunctional enteric-coated capsule). Of the adult cohort, 40 patients were in the control group and 39 in the probiotics group; of the elderly cohort, 28 were in the control group and 26 in the probiotics group. The two groups in both age cohorts were compared in negative conversion time of the SARS-CoV-2 nucleic acid, length of hospital stay, clearance rates of ORFlab gene and N gene, and relief of main symptoms. SPSS 26.0 was used for statistical analysis. According to the data type, t-test, Wilcoxon rank sum test, χ² test, or Fisher exact probability method was used for inter-group comparison. Results In the adult cohort, there was no statistically significant difference in negative conversion time of the nucleic acid, length of hospital stay, ORFlab gene clearance rate, N gene clearance rate, and relief of main symptoms between the control group and the probiotics group. In the elderly cohort, there were statistically significant differences between the two groups in negative conversion time of the nucleic acid [11.0 (9.0,13.0) vs 8.0 (6.0,10.0) d] and the length of hospital stay [10.5 (9.0,13.0) vs 8.0 (6.0,10.0) d] (P<0.05 for both), but there was no statistically significant difference in the clearance rate of ORFlab gene and N gene. The Kaplan-Meier curves showed that there was no statistically significant difference in the median conversion time between the two groups in the adult cohort (7.0 vs 6.0 d; P=0.383), and that there was a statistically significant difference in the elderly cohort (11.0 vs 8.0 d). Conclusion The adjuvant treatment of probiotics can enhance negative conversion of the nucleic acid in the elderly patients with mild COVID-19 caused by Omicron variant.

Abstract:Objective To explore the impact of insulin resistance (IR) on the occurrence of post-stroke depression (PSD) and its predictive value. Methods A total of 242 patients with acute stroke admitted to Department of Neurology of Affiliated Tangshan Worker′s Hospital from October 2021 to September 2022 were subjected in this study. Then according to Hamilton Depression Scale-17 (HAMD-17), they were divided into PSD group (n=69) and non-PSD group (n=173). A self-designed questionnaire was used to collect their clinical data. National Institutes of Health stroke scale (NHISS), Essen stroke risk score (ESRS), and daily ability assessment scale (Barthel index) were employed to evaluate the stroke status. Laboratory indicators, such as lipids, high-sensitivity C-reactive protein (hs-CRP), hemoisocysteine (Hcy), fasting blood glucose (FBG) and fasting insulin (Fins) were collected. After homeostasis model assessment-insulin resistance (HOMA-IR) was calculated, the patients were divided into low-IR group (n=182) and high-IR group (n=60) with HOMA-IR value of P₇₅. SPSS statistics 26.0 was used for data analysis. Depending on data type, student′s t test, Mann-Whitney U test or Chi-square test was performed for comparison between groups. Logistic regression analysis was applied to analyze the effect of IR on PSD. Receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of IR for PSD. Results Significantly higher body mass index, NHISS score, total cholesterol, hs-CRP, Hcy, Fins levels and HOMA-IR, and lower Barthel index were observed in the PSD group when compared with the non-PSD group. The patients of male, and history of hypertension and hyperlipidemia were prone to PSD (P<0.05). Multivariate logistic regression analysis showed that history of hyperlipidemia (OR=3.52, 95%CI 1.44-8.62; P<0.05), NHISS score (OR=1.12,95%CI 1.00-1.25; P<0.05), hs-CRP (OR=1.11, 95%CI 1.04-1.19; P<0.05), Hcy (OR=1.07,95%CI 1.03-1.10; P<0.05) and HOMA-IR (OR=8.84,95%CI 3.86-20.22; P<0.05) were risk factors for PSD. The ROC curve showed that after introduction of HOMA-IR, ROC area under the curve was 0.88 (95%CI 0.84-0.92), sensitivity was 81.2%, and specificity was 78.8% (P<0.001). Conclusion IR is an independent risk factor for PSD. High HOMA-IR level at admission is associated with an increased risk of PSD.

Abstract:Objective To investigate the efficacy of low-molecular-weight heparin calcium combined with physical therapy in the prevention of deep venous thrombosis (DVT) of lower limbs in elderly patients who have been staying in bed for long periods. Methods A total of 119 long-term bedridden elderly patients admitted to Beijing Rehabilitation Hospital from November 2019 to October 2022 were subjected and then randomly divided into control group (59 cases, low-molecular-weight heparin calcium) and the combination group (60 cases, low-molecular-weight heparin calcium combined with physical therapy). Their blood coagulation indicators, hemorrheological parameters, DVT occurrence, and incidence of adverse reactions were observed and compared between the two groups. SPSS statistics 23.0 was used for statistical analysis. Data comparison between two groups was performed using student′s t test or Chi-square test depending on data type. Results After treatment, the combined group had significantly longer thrombin time and prothrombin time, and lower whole blood high shear viscosity, whole blood low shear viscosity and incidence of DVT when compared with the control group [(14.56±2.60) vs (13.02±2.74) s, (13.75±2.86) vs (12.35±2.530 s, (4.66±0.52) vs (5.10±0.87) mPs·s, (10.89±1.43) vs (11.78±1.90) mPs·s, 0 (0.00%) vs 7 (11.86%); P<0.05]. There were no statistical differences in activated partial thromboplastin time, plasma viscosity and incidence of adverse reactions between two groups. Conclusion Combination of low-molecular-weight heparin calcium and physical therapy can improve the blood coagulation status to a certain extent, and reduce the blood viscosity and incidence of DVT in long-term bedridden elderly patients.

Abstract:Objective To compare the efficacy and safety of “piledriving” concept and technique in the ablation of left pulmonary vein anterior triangle during atrial fibrillation (AF) ablation procedure with that of traditional concept and technique. Methods Consecutive 56 patients with paroxysmal AF admitted to Department of Cardiology of First Medical Center of Chinese PLA General Hospital from June 2018 to December 2020 were enrolled, and then randomly assigned into piledriving group and traditional group, with 28 patients in each group. Their baseline data, including age, gender, body mass, history of paroxysmal AF and left atrial diameter were collected and compared. After preoperative examinations, ablation procedure were performed. The patients from the piledriving group were given special piledriving-like ablation at the anterior triangle of left pulmonary vein while those of the traditional group received routine ablation at the anterior triangle. SPSS statistics 21.0 was used for statistical analysis. Data comparison between two groups was performed using student′s t test or Chi-square test depending on data type. Results The “piledriving” group demonstrated significantly shorter left pulmonary isolation time [(39.6±6.2) vs (62.5±8.7) min], bilateral pulmonary isolation time [(106.3±12.8) vs (123.9±17.5) min] and total procedure time [(176.4±29.1) vs (201.2±33.8) min], and obtained obviously higher rate of single circle isolation for left pulmonary vein [82.1% (23/28) vs 60.7% (12/28)] when compared with the traditional group (all P<0.05). There were no statistical differences in the incidence rates of vagus nerve reflex, perioperative adverse events, cardiac tamponade or recurrence during one-year follow-up period. Conclusion Piledriving is a stable and reliable technique for AF ablation, with the advantages of shortening ablation time at the anterior triangle of left pulmonary and improving the rate of single circle isolation for left pulmonary vein, and thus facilitates the total efficiency of surgical procedure. It shows satisfied safety with no elevated adverse reactions, and is an effective measure to deal with operational difficulties due to local anatomical structure.

Abstract:Objective To investigate the correlation between parameters of ambulatory blood pressure and mild cognitive impairment (MCI) among the elderly. Methods A total of 306 retired cadres who had finished the annual health examination at Changhai Hospital from March to July in 2020 were enrolled as the research subjects. Their general data, results of laboratory tests, and medical history were collected. Portable ambulatory blood pressure monitor was used to record the average blood pressure, standard deviation of blood pressure, variation coefficient of blood pressure, morning blood pressure surge and circadian rhythm at the different time intervals. Montreal cognitive assessment (MoCA) was employed to evaluate the cognitive function. According to the results, the subjects were divided into MCI group (n=218) and the normal cognition group (n=88). SPSS statistics 26.0 was adopted for data analysis. Student′s t test, Mann-Whitney U test, or Chi-square test was performed for intergroup comparison depending on data type. Spearman rank correlation analysis was conducted to analyze the correlation of ambulatory blood pressure and MCI. Multivariate logistic regression model was established to analyze the influencing factors for MCI. Results Compared with the normal cognition group, higher average blood pressure, standard deviation of blood pressure, variation coefficient of blood pressure, and circadian rhythm were observed in the MCI group (P<0.05). Correlation analysis indicated that the total MoCA score was negatively correlated with 24-hour mean systolic blood pressure, daytime mean systolic blood pressure, night mean systolic blood pressure, 24-hour mean systolic blood pressure standard deviation, daytime mean systolic blood pressure standard deviation, night mean systolic blood pressure standard deviation, daytime mean diastolic blood pressure standard deviation, 24-hour mean systolic blood pressure coefficients of variation, 24-hour mean diastolic blood pressure coefficients of variation, daytime mean systolic blood pressure coefficiens of variation, night mean systolic blood pressure coeffients of variation, and night mean diastolic blood pressure coeffients of variation (r=-0.151, -0.144, -0.136, -0.202, -0.253, -0.158, -0.253,-0.210, -0.190, -0.220, -0.178, -0.119; P＜0.05), and positively correlated with 24-hour mean diastolic blood pressure, daytime mean diastolic blood pressure, and night mean diastolic blood pressure (r=0.163,0.157,0.138; P＜0.05). Multivariate logistic regression analysis showed that age, 24-hour mean systolic blood pressure coeffients of variation, non-dipper and reverse-dipper in the circadian rhythm (B=11.000, OR=1.115, P<0.01; B=0.270, OR=1.305, P<0.01; B=1.496, OR=4.646, P<0.01; B=1.306, OR=3.690, P<0.05) were independent risk factors for occurrence of MCI among the elderly. Conclusion Ambulatory blood pressure variability is closely associated with the occurrence of MCI among the elderly. Controlling abnormal blood pressure variability may be beneficial in preventing the occurrence of MCI.

Abstract:Objective To investigate the correlation of hyperphosphatemia with cardiovascular parameters, left ventricular hypertrophy (LVH) and aortic calcification (AC), in chronic kidney disease (CKD) patients undergoing maintenance hemodialysis. Methods A total of 465 CKD patients on dialysis admitted to the First Affiliated Hospital of Chongqing Medical University from January 2018 to March 2019 were enrolled in this retrospective study. Their baseline data, laboratory indicators, two-dimensional echocardiogram, chest CT plain scan, and chest X-ray films were collected. For the 328 patients who received two-dimensional echocardiography, they were divided into LVH group (n=234) and non-LVH group (n=94) based on the presence or absence of LVH. While, the 330 patients who underwent chest CT plain scan or chest X-ray examination were divided into AC group (n=199) and non-AC group (n=131). The 269 patients who underwent both two-dimensional echocardiography and chest CT plain scan or chest X-ray examination were divided into low, normal and high serum phosphorus groups (serum phosphorus level:<0.81,0.81-1.45, >1.45 mmol/L; n=36,106, 127, respectively). SPSS statistics 26.0 was used for data analysis. Depending on data type, student′s t test, Mann Whitney U test, or Chi-square test was used for intergroup comparison. Multivariate logistic regression model was performed to analyze the relationship of serum phosphorus level with LVH and AC. Results The LVH group had significantly older age [(49.25±13.52) vs (52.78±12.34) years], higher systolic blood pressure [(150.80±25.19) vs (144.00±24.94) mmHg (1mmHg=0.133kPa)], diastolic blood pressure [(85.50±18.18) vs (79.96±14.80) mmHg] and serum phosphorus level [(1.97±0.76) vs (1.73±0.73) mmol/L], and larger proportion of diabetes [25.21% (59/234) vs 15.96% (15/94)], but obviously lower hemoglobin [(98.51±26.10) vs (107.05±26.48) g/L], serum calcium [(2.07±0.29) vs (2.16±0.31) mmol/L] and albumin [(38.09±5.94) vs (39.74±5.77) g/L] when compared with the non-LVH group (all P<0.05). Statistically older age [(57.82±10.32) vs (45.87±11.75) years], higher hemoglobin [(102.22±24.57) vs (94.55±28.16) g/L], serum calcium [(2.16±0.28) vs (2.00±0.31) mmol/L], serum phosphorus [(1.99± 0.76) vs (1.81±0.74) mmol/L], calcium phosphorus product [(52.70±20.02) vs (44.54±18.42) mg/dl] and proportions of diabetes [28.64% (57/199) vs 15.27% (20/131)] and hypertension [28.64% (57/199) vs 15.27% (20/131)], and lower diastolic blood pressure [(81.67±15.00) vs (87.31±19.35) mmHg] and usage rate of phosphorus lowering drugs [39.70% (79/199) vs 55.73% (73/131)]were observed in AC group than in non-AC group (all P<0.05). Multivariate logistic regression analysis showed that increased diastolic pressure (OR=1.017,95% CI 1.001-1.033; P=0.038), increased serum phosphorus (OR=1.581,95%CI 1.080-2.316; P=0.019), diabetes mellitus (OR=0.540,95%CI 0.296-0.987; P=0.045) and decreased albumin (OR=0.934,95%CI 0.891-0.979; P=0.004) were independent risk factors for LVH in maintenance hemodialysis patients. Age (OR=1.091,95%CI 1.067-1.117; P<0.001), elevated serum phosphorus (OR=0.307,95% CI 0.128-0.734; P=0.008), calcium phosphorus product (OR=1.085,95%CI 1.046-1.125; P<0.001), and diabetes mellitus(OR=2.039,95% CI 1.041-3.995; P=0.038) were independent risk factors for AC in these CKD patients on maintenance hemodialysis. The incidence of LVH was significantly higher in the high serum phosphorus group than the normal serum phosphorus group [80.31% (102/127) vs 61.32% (65/106); P<0.05]. Conclusion Hyperphosphatemia is an independent risk factor for LVH and AC in CKD patients undergoing maintenance hemodialysis. Controlling hyperphosphatemia is essential to improve cardiovascular disease in CKD patients.

Abstract:Objective To investigate the delaying effect of omega-3 polyunsaturated fatty acids (n-3PUFAs) on D-galactose (D-gal) induced skeletal muscle aging in rats and its possible mechanism. Methods Thirty elderly male Wistar rats were randomly divided into blank group (0.9% normal saline injection), model group (rat model of skeletal muscle aging) and n-3PUFAs group (aging model+n-3PUFAs feeding), with 10 rats in each group. The growth, body mass, mass of soleus muscle and strength of limb muscle were compared among the rats in each group to explore the effect of n-3PUFAs on muscle regeneration in aging muscle atrophy rats. Western blot was used to detect the expression levels of calcium/calmodulin-dependent protein kinase 2 (CAMKK2) and adenosine monophosphate activated protein kinase (AMPK). SPSS statistics 21.0 was adopted for statistical analysis. One-way analysis of variance was employed for multiple group comparison, and LSD-t test was performed for pairwise multiple comparisons. Results Compared with blank group of rats [(466.04±33.83) g], the body mass of model group [(403.33±25.37)g] and n-3PUFAs group [(435.72±27.32)g] reduced; compared with model group,the body mass of rats in the n-3PUFAs group increased, the differences were statistically significant (P<0.05). Compared with blank group, the time began to climb of model group rats were longer after 1 month [(2.40±0.50) vs (1.07±0.15) s]and 2 months [ (7.33±0.76) vs (1.33±0.32)s]; compared with model group, the time required for n-3PUFAs group rats were shorter after 1 month [(1.76±0.32) vs (2.40±0.50)s] and 2 months [ (4.07±0.61) vs (7.33±0.76)s], the differences were statistically significant (P<0.05). Compared with blank group, the gap between skeletal muscle cells in the model group increased, the diameter of muscle fibers decreased, and the expression of p21 and p16 proteins was upregulated; the differences were statistically significant (P<0.05). Compared with model group, the gap between skeletal muscle cells in the n-3PUFAs group decreased, the diameter of muscle fibers increased, and the expression of p21 and pl6 proteins were downregulated; the differences were statistically significant(P<0.05). Compared with blank group, the relative protein expression of CaMKK2 and p-AMPK in the model group decreased; compared with model group, the expression of CaMKK2 and phosphorylated p-AMPK relative protein in n-3PUFAs group increased; the differences were statistically significant (P<0.05). The expression level of AMPK in the three groups had no significant difference (P>0.05). Conclusion n-3PUFAs can delay skeletal muscle aging induced by D-gal in rats, and its mechanism may be related to the up-regulation of key proteins in CaMKK2/AMPK signaling pathway.

Abstract:With acceleration of population aging in recent years, more and more people are suffering or will soon suffer from age-related hearing loss, causing a huge inconvenience for their work and life. Therefore, the importance of a precise and rapid diagnosis of diseases associated with hearing loss in the elderly population is self-evident. The construction and development of imaging technologies, mainly computed tomography, magnetic resonance multimodality imaging, and molecular imaging, is providing an important objective basis for diagnosis and efficacy prediction of diseases associated with hearing loss in the elderly population. This paper reviews research progress in imaging for age-related hearing loss.

Abstract:Iron is an important trace element in human body and has important physiological functions. There is a precise mechanism to regulate physiological metabolism of iron in the body. When iron homeostasis in the brain is out of balance and abnormal iron deposition occurs, cell damage can be caused, and this process is closely related to the aging of the brain. This paper briefly summarized the regulatory mechanism of iron homeostasis in the body and its relationship with aging and life expectancy, elaborated the close relationship between brain iron deposition and aging, and reviewed the latest research progress of determination methods of brain iron deposition and iron removal therapy. We hope that this review can provide a reference for the research of iron metabolism and aging related nervous system diseases.

Abstract:At present, great progress has been made in the study of cervical sagittal balance parameters, and many scholars have devoted themselves to investigate the relationship of these parameters with adjacent segment degeneration (ASD). The preliminary results are satisfying. ASD patients often have cervical sagittal imbalance, with varying variations in different parameters. And there are strong correlations among these parameters. At the same time, the preoperative age of patients, severity of cervical degeneration, surgical methods, and selection of surgical segments also have a significant impact on the occurrence of ASD.

Abstract:Sepsis is frequently associated with hemodynamic instability and complicated pathophysiological process. Its hemodynamic treatment aims aimed to restore microcirculatory perfusion, ensure oxygen uptake rate of tissue cells, protect cardiac function, and promote early repair of cardiomyocytes, thereby improving the patient′s prognosis. However, no specific drug is available for the treatment of hemodynamic disorders in sepsis. The Traditional Chinese Medicine (TCM) offers theoretical basis of intervention in sepsis. This article reviews the current cognition of hemodynamic disorders in sepsis and the feasibility of TCM intervention, hoping to provide new insights and directions for its clinical treatment.

Abstract:Diabetic nephropathy, as the most common microvascular complication of mellitus diabetes, is the most important cause of end-stage renal failure worldwide and seriously affects the life quality of patients. The pathogenesis of diabetic nephropathy is complex, and currently are mainly known as glucolipid metabolic disorder, oxidative stress, and inflammatory response. Through searching ancient books and literature review, in combination with the experience of medication of national famous veteran Chinese medicine practitioners, such as Lyu Renhe, Zhao Jinxi and Huang Wenzheng, it was found that Euonymus alatus (Ramulus Euonymi) was widely used in wasting-thirst (diabetes). Modern pharmacological studies have found that this herb play a role in protecting the kidneys and slowing the progression of diabetic nephropathy. In this article, we review the mechanism and recent researches of Euonymus alatus in the treatment of diabetic nephropathy in order to provide new ideas for clinical research.