Abstract:Objective To investigate the status and the possible influencing factors of blood pressure control in hypertensive population from the rural areas of Northwest China. Methods Hypertensive patients (permanent residents of 3 natural villages of Yangxiaba Town, Wuwei City, Gansu Province) enrolled in a hypertension management system before July 2017 were recruited and surveyed through questionnaires. Their demographic characteristics, life style, medical history, family history and drug use were investigated, and physical examination (height, body mass and blood pressure) and laboratory examination were carried out. SPSS statistics 23.0 was used to analyze the data. One-way analysis of variance (ANOVA), Student’s t test or Chi-square test was employed for the comparison between groups. Multivariate analysis were carried out with multiple linear regression and multivariate logistic regression analysis. Results The recruited 512 hypertensive patients were at an age of (64.7±9.7)years. Among them, 72.3%(370/512) participants took antihypertensive drugs, with a rate of blood pressure control of 59.2%(219/370). Single factor analysis showed that the participants from Xiaergou Village, and taking antihypertensive drugs and doing no farm work, had higher systolicblood pressure (SBP), while those with age ≥65 years, overweight/obesity, from Xiaergou Village, receiving antihypertensive drugs, no history of cardiovascular disease, and having family history of hypertension, had higher diastolic blood pressure (DBP). Multiple linear regression analysis indicated that SBP was positively correlated with receiving antihypertensive drugs (β=0.173) and LDL-C level (β=0.107), and negatively with farm work (β=-0.119). While, DBP was positively correlated with age (β=0.247) and receiving antihypertensive drugs (β=0.156), but negatively with history of cardiovascular disease (β=-0.115), farm work (β=-0.103) and HDL-C level (β=-0.104). The results of single factor analysis for blood pressure control showed that significant differences were found among different areas (P=0.001), taking part in farm work or not (P=0.033) and receiving antihypertensive drugs or not (P<0.05). Multivariate logistic regression analysis indicated that farm work (OR=0.632,5%CI 0.429-0.933; P=0.021), from Sangou Village (OR=0.416,5%CI 0.262-0.660; P<0.001) and Wugou Village (OR=0.587, 95%CI 0.378-0.911; P=0.018) were protective factors for blood pressure control. Conclusion Apart from standardized antihypertensive medication, healthy life styles should also be encouraged for hypertensive patients. Those from rural areas should take part in farm work to well control blood pressure.

Abstract:Objective To investigate the magnesium disorder and determine the effect of serum magnesium level on short-term prognosis in the old patients with acute kidney injury (AKI). Methods The old male patients(≥75 years old) with AKI admitted in the Geriatric Department of our hospital between January 2007 and December 2015 were enrolled in this study. According to their outcomes in 28 d and from 29 to 60 d after AKI respectively, they were also divided into survival and death groups. Hypomagnesemia is defined as serum magnesium <0.7 mmol/L, and hypermagnesemia as >1.1 mmol/L. SPSS statistics 17.0 was used to perform the statistical analysis. The survival curves were estimated by Kaplan-Meier (product-limit) Estimator, and compared by Mantel (log-rank) test. Multivariate Cox proportional regression model was used to analyze the effect of serum magnesium on short-term survival in elderly patients. Results There were 623 old male AKI patients included, at a median age of 87(84,91) years, including 473 patients (75.9%) in the normal magnesium, 72(11.6%) in hypomagnesemia, and 78(12.5%) in hypermagnesemia. One hundred and sixty patients (24.5%) died within 28 d after AKI, and 194 cases (29.8%) died within 60 d. The Kaplan-Meier survival curve showed the high magnesium patients had worse 28-day survival (log rank P=0.001). Multivariate Cox analysis revealed that time of AKI diagnosis (HR=0.865,5%CI 0.799-0.937; P<0.001), mean aortic pressure(HR=0.970, 95%CI 0.958-0.981; P<0.001), serum prealbumin level(HR=0.924,5%CI 0.894-0.955; P<0.001), oliguria (HR=2.261, 95%CI 1.424-3.590; P=0.001), mechanical ventilation(HR=1.492,5%CI 1.047-2.124; P=0.027), blood urea nitrogen level (HR=1.037, 95%CI 1.025-1.049; P<0.001), magnesium level (HR=2.512,5%CI 1.243-5.076; P=0.010) and AKI stages (stage 2:HR=3.709, 95%CI 1.926-7.141, P<0.001; stage 3:HR=5.660,5%CI 2.990-10.717, P<0.001) were the influencing factors for 28-day mortality. However, no significant difference was found in serum magnesium level for 29 to 60-day mortality. Conclusion The incidence of magnesium disorder is up to 24.1% in old male AKI patients. High serum magnesium level is associated with 28-day mortality, so more intensive monitoring and appropriate correction of serum magnesium level may prolong their survival time.

Abstract:Objective To survey the current status of chronic diseases in 92 longevous old people living in Zhongxiang City in order to provide a scientific basis to improve their quality of life. Methods According to the demographic information provided by Zhongxiang Bureau of Civil Affairs, 92 longevous people (≥90 years old) who were residents in 11 villages or towns were visited and surveyed during January 2013 and April 2017. They were 18 males and 74 females, and at an age of 90-113 (99.3±4.7) years. Comprehensive health assessment and chronic diseases survey were carried out on the subjects by trained staffs. The differences between the males and the females were investigated. SPSS statistics 20.0 was used to perform the statistical analysis. Student’s t test, Chi-square test, or Fisher’s exact test was employed for the comparison between the 2 groups. Results The results of the comprehensive health assessment showed that the longevous subjects were in good health. Most of them could take care of themselves and complete daily activities such as dressing, bathing and walking. Some subjects (41.30%, 38/92) had normal cognition, while some (46.74%, 43/92) had mild cognitive dysfunction, but were able to communicate well with their relatives and others. Only 18.48% (17/92) of the participants had depressive symptoms. The World Health Organization Quality of Life (WHOQOL)-BREF Scale showed that the elderly had good quality of life and high self-satisfaction. Compared with the female subjects, the male ones had higher ratio of living alone (χ²=7.031, P<0.05), lower ratio of illiteracy (χ²=9.218, P<0.05), and higher ratio of smoking history (χ²=31.2, P<0.001). Each person suffered from 1 to 7 (3.13±1.32) kinds of chronic diseases. Only 10.87%(10/92) participants had only 1 chronic disease, 88.04%(81/92) had 2 to 6 kinds, and 1.09%(1/92) had even 7 kinds. Among the 16 common chronic diseases, the top 3 were hypertension (72.83%, 67/92), malnutrition and risk of malnutrition (61.95%, 57/92), anddyslipidemia 58.70% (54/92). There was no significant difference in the comorbid conditions between the male and female subjects (P>0.05). Conclusion The prevalence rate of hypertension is the highest, while those of diabetes, dementia and cancer are quite low in the longevous people in Zhongxiang City. Although most of them suffer from a variety of chronic diseases, they still can complete basic daily activities and enjoy good mental status. However, improving their nutritional status and being cautious for falls are of great significance to reduce their morbidity and thus improve their quality of life.

Abstract:Objective To determine the effect of retrobular injection of triamcinolone acetonide on blood glucose in the elderly patients with diabetic and non-diabetic macular edema (ME). Methods A total of 80 elderly patients (over 65 years old)with diabetic and non-diabetic ME admitted in Ophthalmological Department of our hospital from December 2015 to November 2016 were enrolled in this study. They were divided into diabetic and non-diabetic groups, with 40 cases(40 eyes) in each group, and underwent retrobulbar injection of 20 mg triamcinolone acetonide.Fasting plasma glucose(FPG) and 2-hour postprandial blood glucose (2hPBG) were mea-sured on the day of treatment (before treatment), on continuous 7 days and in 14 d(2 weeks) after treatment. SPSS statistics 17.0 was used to perform the statistical analysis. Analysis of variance was employed for the intra-group comparison, and independent sample t test for comparison between groups. Results The FPG [(5.35±0.33)mmol/L] and 2hPBG [(7.66±0.34)mmol/L] levels reached the highest values on day 2 in the non-diabetic group, but for the diabetic group, the peak values were observed on day 2 [(8.53±0.59)mmol/L]and day 3 [(13.32±2.70)mmol/L]respectively, with statistical significances in the time points. There were no differences in blood glucose level in the non-diabetic group on days 4,5,6,7 and 14 with that before treatment. But, the level was obviously increased in the diabetic group even on day 14 when compared with that before treatment. What’s more, the maximum difference of FPG [(0.65±0.21) vs (2.91±0.27)mmol/L] and 2hPGB [(1.10±0.37) vs (4.59±2.15)mmol/L] were more significantly increased in the diabetic group than in the non-diabetic group (P<0.01). Conclusion Retrobular injection of triamcinolone acetonide results in increased blood glucose, with the peak on day 2 or 3 after injection, and the effect is more significant for diabetic patients. Ophthalmologists should pay great attention on systemic side effects of such drugs.

Abstract:Objective To investigate the types of chronic diseases and distributions and patterns of multimorbidity in the very old inpatients. Methods Clinical data of 1004 elderly hospitalized patients in the Department of Geriatrics of our hospital from June 2013 to June 2016 were collected and retrospectively analyzed. Based on the presence of 23 common chronic conditions, types of these diseases and characteristics of chronic comorbidities were investigated. Student’s t test or one-way analysis of variance was employed for statistical analysis in measure data, and Chi-square test was used for enumeration data.Results Among the 23 obtained chronic diseases, the top 5 common ones were hypertension (72.51%), cerebrovascular disease (52.29%), coronary heart disease (37.25%), cardiac insufficiency (36.25%), and bone and joint disease (33.96%). The rate of multimorbidity (≥2 disease) was 93.73% in the cohort, and the mean number of comorbid conditions was (4.67±2.18). The observed prevalence of paired chronic conditions exceeded the expected prevalence for several paired conditions, such as hypertension and diabetes mellitus(OR=1.25, 95%CI 1.02-1.54; P=0.03), coronary heart disease and cardiac insufficiency(OR=2.14, 95%CI 1.69-2.69; P<0.01), and cardiac insufficiency and arrhythmia(OR=1.77, 95%CI 1.34-2.35; P<0.01). Conclusion The very old individuals show characteristics of higher prevalence of multimorbidity and greater number of chronic diseases or conditions. These conditions may be associated with each other and form special paired chronic conditions.

Abstract:Objective To investigate the status of knowledge-attitude-practice (KAP) on blood lipids and influencing factors among the retired cadres living in Huangpu District of Shanghai in order to provide references for the prevention and control of blood lipid abnormality among the elderly. Methods Totally 410 retired cadres living in Huangpu District were randomly sampled. They all underwent blood lipid test and KAP questionnaire survey on blood lipid. According to the results of blood lipid test, they were divided into normal blood lipid group (control group, n=120,2 males and 48 females) and abnormal blood lipid group (study group, n=290, 169 males and 121 females). The KAP scores were compared between the 2 groups, and the influencing factors of the scores were analyzed. SPSS statistics 18.0 was used to analyze the data. Student’s t test, Chi-square test or variance analysis were used for the intergroup comparison. Multivariate linear stepwise regression analysis were employed to analyze the factors affecting KAP scores. Results In the study group, the female subjects had significantly higher practice score than the males [(9.74±1.80) vs (7.65±2.98)score; P<0.05]. Compared with the control group, the subjects with college or above education levels had higher scores in knowledge and attitude [(21.02±8.56) vs (17.50±8.77)score, (7.27±1.69) vs (6.82±1.81)score; P＜0.05), and those complicated with hypertension had higher scores in attitude [(7.75±1.75) vs (6.86±1.65)score; P＜0.05], but those with coronary heart disease had lower scores in knowledge, attitude and practice (all P<0.05). Multiple factors linear stepwise regression analysis showed that the knowledge score was mainly influenced by the attitude score, age and education level, the attitude score by the practice score, knowledge score, age and systolic blood pressure, while the practice score by the attitude score, body mass, fasting blood glucose and uric acid. Conclusion For the elderly, especially those with abnormal blood lipids, senior aged, lower education levels, and those complicated with hypertension, hyperuricemia, hyperglycemia, and/or coronary heart disease, it is helpful to carry out heath education on blood lipids, promote the knowledge, and advocate the scientific diet structure, healthy exercise and life style habits to reduce the risk of blood lipid abnormality and cardiocerebral vascular diseases.

Abstract:Objective To investigate the effect of functionally complete revascularization guided by fractional flow reserve (FFR)on the prognosis in the patients with non-ST segment elevation acute coronary syndrome(NSTE-ACS) and multi-vessel disease (MVD). Methods A total of 100 NSTE-ACS and MVD patients admitted in the Cardiological Department of the Hanzhong People’s Hospital from January to July 2016 were enrolled in this study. They were randomly divided into FFR group (undergoing functionally complete revascularization guided by FFR) and CAG group (receiving coronary angiography guided PCI treatment). The number of implanted stents, hospitalization expenses, and data of PCI were compared between the 2 groups.In the follow-up of 12 months,angina attacks, left ventricular ejection fraction(LVEF) and occurrence of major adverse cardiovascular events (MACEs) were also compared. SPSS statistics 19.0 was used for data processing. Student’s t test or Chi-square test were used to compare the differences between groups. Results Compared with the CAG group, the FFR group had less implanted stents [(2.0±1.5) vs (3.5±1.8), P<0.01] and lower hospitalization expenses [(43905±26242) vs (65884±20489)CNY, P=0.04], and better improved angina symptoms [(2.3±0.7) vs (4.1±0.5)times] and LVEF [(62.7±6.8)% vs (54.7±7.9)%]. The incidences of revascularization [4.1%(2/49) vs 17.7%(8/45), P=0.03] and MACEs [8.2%(4/49) vs 24.4%(11/45), P=0.03] were also significantly lower in the FFR group than in the CAG group. Conclusion Functionally complete revascularization guided by FFR significantly reduces the number of stents and hospitalization expenses, effectively improves the symptoms of angina attacks and heart function, and decreases the incidence of MACEs in 12 months after surgery. The approach shows obvious short-term benefit to the NSTE-ACS and MVD patients.

Abstract:Objective To summarize the clinical characteristics of ischemic colitis (IC) between the elderly and young/middle-aged patients. Methods Clinical data of 200 IC patients with definite diagnosis from June 2010 to December 2016 in our department were collected and retrospectively analyzed. The patients were divided into young/middle-aged group (<60 years old, n=78) and elderly group (≥60 years, n=122). The baseline data, clinical manifestations, laboratory examination results, endoscopic findings, clinical course and outcomes after treatment were analyzed and compared between the 2 groups. SPSS statistics 13.0 was used to perform the statistical analysis. Student’s t test or Chi-square test was employed for comparison between the 2 groups based on different data types. Results When compared with the elderly group, the young/middle-aged group took obviously higher ratios of the subjects with fatty liver and histories of constipation and abdominal operation, while notably lower ratios of hypertension and coronary heart disease (P＜0.05), and remarkably lower ratio of nausea and vomiting (P＜0.01). The levels of platelet (PLT) and fibrinogen (Fg) were significantly lower, while activated partial prothrombin time (APTT) was obviously longer in the young/middle-aged group than in the elderly group (P＜0.05). The endoscopic findings showed that the bowel lesions in the left colon was remarkably higher in the young/middle-aged group than in the elderly group [92.3% (72/78) vs 73.0% (89/122)], while those in the right colon was opposite [7.7% (6/78) vs 27.0% (33/122),P＜0.01]. There was no significant difference between the 2 groups in mucosal congestion and edema, scattered erosion, ulcer and bleeding, and ratio of intestinal stricture (P>0.05). The percentage of completely healed mucosa was 96.2% (75/78) in the young/middle-aged group, and was 91.0% (111/122) in the elderly group (P=0.162). Conclusion The major causes of IC are intestinal factors for young/middle-aged patients, while vascular factors for the elderly. Blood hypercoagulability is common in elderly IC patients.

Abstract:Objective To investigate the effect of brisk walking on sleep disorders in Alzheimer[KG-*3]’[KG-*3]s disease

Abstract:Objective To determine the efficacy of laparoscopic and open neoplasty on elderly patients with duodenal ulcer perforation (DUP). Methods Totally 100 elderly DUP patients admitted in our hospital from March 2014 to March 2017 were enrolled in this study. According to the treatment, they were divided into laparoscopy group and open surgery group, with 50 patients in each group. The therapeutic efficacy, incidences of complications and serum motilin level were compared between the 2 groups. SPSS statistics 22.0 was used for data processing. Student’s t test or Chi-square test was employed for the comparison between groups according to the data types. Results The time of getting out of bed [(28.87±3.07) vs (38.02±4.22) h], length of hospital stay [(3.69±0.82) vs (5.75±1.03) d], time to first flatus [(15.08±1.63) vs (27.36±2.86) h], time to bowel sound [(64.58±6.62) vs (81.46±8.36) h], intraoperative blood loss [(52.45±5.27) vs (76.74±8.04) ml], and incidence of complications (10.00% vs 28.00%) were significantly lower in the laparoscopic group than in the open surgery group. The patients of the laparoscopic group also had higher serum motilin level in 1 d [(182.43±19.52) vs (233.59±25.47) ng/L] and 2 d [(156.37±16.24) vs (180.42±20.18) ng/L] postoperatively when compared with the other group (P<0.05). In 3 months’ follow-up, the excellent healing rate was obviously higher in the laparoscopic group than in the open surgery group (96.00% vs 80.00%, P<0.05). Conclusion Compared with open surgery, laparoscopic neoplasty effectively reduces the trauma and occurrence of complications in elderly DUP patients, and is beneficial for the postoperative recovery of gastrointestinal function. It is worth of further clinical promotion.

Abstract:Objective To determine the effects of ephedrine premedication on hemodynamics in the elderly patients with low physical capacity receiving analgesic gastroscopy under intravenous anesthesia. Methods A total of 70 elderly patients with low physical capacity who were scheduled for analgesic gastroscopy in the Affiliated Hospital of Xuzhou Medical College from April to August 2017 were recruited in this study. They were randomly assigned to propofol group (control group) and propofol+ephedrine group (ephedrine group), with 35 patients in each group. Gastroscopy was performed only after the patients falling asleep, with eyelash reflex disappearance and steady breathing. Heart rate (HR), mean arterial pressure (MAP) and pulse oxygen saturation (SpO₂) were observed and measured at the following time points:before the induction of anesthesia (T₁), 1 min after induction of anesthesia (T₂), at the time or in 3 min after gastroscope placement (T₃ and T₄), at the time or in 5 min after gastroscope withdrawing (T₅ and T₆), and at the time of waking-up (T₇). The amount of propofol, anesthetic effect (excellent rate), discharge time and occurrence of adverse reactions were recorded in both groups. SPSS statistics 22.0 was used to perform the statistical analysis. Student’s t test, rank sum test, repeated measures analysis of variance or Chi-square test was employed for different data types. Results In the control group, HR was lower at the time points T₂-T₆ than at T₁ (P<0.05), and the rate was also lower at T₄ and T₆ than T₁ in the ephedrine group. The ephedrine group had significantly higher HR at T₂ and T₃ than the control group [(76.29±10.59) vs (69.46±8.49) times/min, (81.09±10.16) vs (74.97±8.16)times/min, P<0.05]. MAP was lower in both groups at the time points of T₂-T₇ than T₁ (P<0.05),but the ephedrine group had obviously higher MAP than the control group at T₂-T₆ [(88.71±6.75) vs (77.29±9.82)mmHg, (93.60±7.38) vs (86.97±10.79)mmHg, (87.09±5.90) vs (81.51±9.92)mmHg, (90.26±5.58) vs (86.34±11.81)mmHg, (83.60±6.56) vs (75.66±10.36)mmHg, P<0.05]. For SpO₂, the value was notably lower in the 2 groups at T₆ than T₁ (P<0.05), and it at T₂, T₃ and T₅ was significantly increased than that of T₁, but there was no significant difference in SpO₂ between the 2 groups at every time point (P>0.05). Compared with the control group, the pain rate and pain score in the ephedrine group were significantly lower [7(20%) vs 14(40%), 1(0,2) vs 0(0,1) scores, P<0.05]. The incidence of blood pressure decrease was significantly reduced in the ephedrine group than in the other group [3(9%) vs 20(57%), P<0.05], and the incidence of other adverse reactions was not statistically significant. Conclusion Premedication of ephedrine can reduce the variability of hemodynamics in the elderly patients with low physical capacity undergoing analgesic gastroscopy. It is helpful to maintain the stability of the circulatory function, and can reduce the incidence and intensity of pain, with safety and reliability.

Abstract:Objective To investigate the expression of non-phagocytic cell oxidase (Nox), reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, in mice of lipopolysaccharide (LPS)-induced acute myocardial injury and its significance. MethodsSPF male C57/BL6 mice (8-10 weeks old) were randomly assigned into control group (normal saline,n=15) and LPS group (n=15). LPS group was injected with large dose of LPS (10 mg/kg) to induce acute myocardial injury model, and the control group was only injected with saline equivalent. The mice were sacrificed in 6 h later, and the heart tissues were harvested. The mRNA and protein levels of Nox 2, Nox 4, Bcl-2-associated X protein (Bax), B cell lymphoma/leukemia-2 (Bcl-2) and cysteine aspastic acid-specific protease 3 (Caspase 3) were detected by RT-PCR and Western blotting respectively. The expression of lipid peroxidation products (4-HNE) in the myocardium was measured by immunohistochemistry. TUNEL was used to detect myocardial apoptosis. SPSS statistics 13.0 was used to perform the statistical analysis, and student’s t test was employed for comparison between groups. ResultsCompared with the control group, the mRNA and protein levels of Nox 2, Nox 4 and Bax were significantly increased, while those of Bcl-2 were decreased, and the protein expression of Caspase 3 was elevated in the LPS group (P<0.05). Immunohistochemical assay showed that the expression of 4-HNE was significantly higher in the mice of the LPS group (P<0.05). TUNEL assay indicated that there were more apoptotic cells in the LPS group (P<0.05). Conclusion NADPH oxidase takes part in the occurrence and development of acute myocardial injury through regulating oxidative stress and cell apoptosis.

Abstract:Early diagnosis and treatment of vascular cognitive impairment (VCI) are of great significance to reduce the occurrence of dementia. White matter lesions (WML) within the cholinergic pathways is quite common in the VCI patients. The WHL damage in the pathways can be directly evaluated by Cholinergic Pathways Hyper-intensities Scale (CHIPS) and diffusion tensor imaging, which is time-consuming, easy to operate and comparatively objective. This article summarized the relationship between WML within the cholinergic pathways and cognitive function in VCI patients. The review displays that there are WML within the cholinergic pathway in all the 3 stages of VCI, brain-at-risk, mild cognitive impairment and dementia. In addition, a negative correlation is seen between the severity of WML in the pathways and cognitive function, which provides a valuable imaging reference for early screening and diagnosis of VCI.

Abstract:For the patients with moderate-grade stable coronary artery disease (CAD), it is crucial to determine whether the lesions have significant influences on distal hemodynamics of the coronary arteries (myocardial ischemia) in the process of clinical decision-making. And in these critical conditions, fractional flow reserve (FFR) is the golden standard for identifying the presence or absence of myocardial ischemia. In recent years, with the development of computational fluid dynamics (CFD), a new technology, namely FFRCT, has been developed to calculate FFR values non-invasively based on coronary CT angiography (CCTA). In this review, we elucidated the concepts and application principles of FFRCT, and summarized several current clinical trials concerning the technique, and indicated its good diagnostic performance, clinical practice, advantages, limitations and clinical application prospects.

Abstract:Whey protein, the main fraction of the proteins in mammalian milk, is proven to improve body immunity, possess anti-free radical and anti-aging effects, maintain kidney function and promote wound healing, etc, but also can prevent hypertension, hyperlipidemia, diabetes mellitus, and hyperviscosity. In recent years, some studies have shown that whey protein plays an important role in the treatment of malnourished patients with colorectal cancer. It can significantly improve the nutritional status, reduce post-operative complications and mortality, and decrease the adverse reactions caused by chemotherapy in the patients. In this article, we reviewed the characteristics of whey protein and the relative researches in the treatment of malnourished patients with colorectal cancer.

Abstract:Cardiovascular disease (CVD) has emerged as the leading cause of death worldwide. Acute coronary syndrome (ACS), one of the most harmful cardiovascular events, is, in most cases, triggered by the rupture of a vulnerable plaque followed by thrombosis formation at the rupture site. Deep understanding of vulnerable plaque formation can greatly impact therapeutic approaches for both prevention and treatment of acute cardiovascular events. In the article, we reviewed the concept, characteristics and the pathological mechanisms of vulnerable plaque.

Abstract:Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme reductase, can significantly reduce the incidence of atherosclerotic cardiovascular disease (ASCVD) events. Recently, some guidelines and consensus have suggested that the patients with acute coronary syndromes (ACS) should start high-intensity statin therapy early after admission. But, Chinese patients tend to have higher incidence of side effects in statins treatment than Caucasians. Therefore, particular attention should be paid to the adverse reactions in Chinese population after high-intensity statin treatment. In this article, we reviewed the safety of high-intensity statin therapy in ACS patients in China, and provides a reference for clinical practice.