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Abstract:Objective To summarize the experience of perioperative management of patients with old myocardial infarction undergoing abdominal surgery.Methods Perioperative management of 35 cases with old myocardial infarction undergoing abdominal surgery was analyzed

Abstract:Objective To observe the difference in the clinical characteristics,treatment and prognosis between acute respiratory distress syndrome (ARDS) patients with different causes (pulmonary and extra-pulmonary). Methods Sixty-two ARDS patients in ICU of Beijin

Abstract:目的合并阻塞型呼吸暂停的老年慢性收缩性心力衰竭患者,在常规药物治疗基础上,观察持续正压气道通气方法的临床疗效。方法门诊或住院的老年慢性收缩性心力衰竭患者,夜间多导睡眠诊断合并阻塞型呼吸暂停的患者61例,按照随机方法分为研究组(29例)和对照组(32例),药物治疗病情平稳2周后,研究组加用持续正压气道通气治疗,对照组继续药物治疗,8周后比较两组临床表现、超声心动图指标和血清B型钠尿肽的变化情况。结果与对照组相比,研究组8周治疗后6min步行试验增加(103±93)m(P<0.01),心率平均下降(7±2)次/min(P<0.01)、收缩压平均下降(10±3)mmHg(P<0.05),舒张压变化不明显;左室射血分数明显提高5%(P<0.05),左室收缩末径下降2mm(P<0.05),每搏输出量增加4ml/次(P<0.01),血清B型钠尿肽下降651ng/L(P<0.01)。结论对于合并阻塞型呼吸暂停的老年慢性收缩性心力衰竭患者,常规药物治疗基础上加用持续正压气道通气方法,有利于改善患者的心功能,改善心肌重塑。

Abstract:目的探讨在入院时及出院后持续使用大剂量他汀调脂治疗的急性心肌梗死（AMI，包括非ST段抬高者在内）患者，因各种原因中断大剂量治疗后血清炎症标识物水平的变化。方法接受标准治疗的急性心肌梗死患者（均接受了冠脉介入治疗），在入院24h内即开始使用大剂量的阿托伐他汀（40mg／d）治疗，并在住院期间及出院后继续使用阿托伐他汀（40mg／d），出院后均接受长期随访，分别在入院时及出院后1、3、6个月检测所有患者的高敏C反应蛋白（hs-CRP）、白介素-6（IL-6）等炎症标记物水平。根据随访结果分为持续大剂量（40mg／d）用药组（A组，50例）和大剂量中断组（B组，0-20mg／d，62例），比较两组患者在各时期炎症标识物水平的变化。结果（1）两组患者出院后除他汀药物外的其他治疗情况无明显不同；两组患者均接受了至少1个月的大剂量调脂治疗。（2）两组患者的hs-CRP、IL-6等水平随服用时间的延长逐渐降低，但B组患者在中断大剂量治疗后hs-CRP、IL-6的降低程度不如A组；第6个月时B组患者的hs-CRP及IL6水平均显著高于同期的A组患者（hs-CRP：2.62（1．41～16．12）mg／L vs 1．53（0．36～7．92）mg／L，P〈0．01；IL-6：9．61（3．26～17．86）ng／L vs 5．26（0．20～10．51）ng／L，P〈0．05]。结论急性心肌梗死患者长期坚持大剂量他汀调脂治疗后hs-CRP等炎症标识物水平持续下降，中断大剂量治疗后炎症标识物水平将逐渐升高。

Abstract:Objective To analyse the chinicopathological characteristics of multiple organ failure in the elderly (MOFE) complicated by alimentary tract hemorrhage. Methods The clinicopathological data of MOFE patients complicated with alimentary tract hemorrhage dia

Abstract:Objective To observe clinical features of chronic obstructive pulmonary disease(COPD) in the elderly. Methods A total of 206 patients with COPD were retrospectively analyzed. Results Of these COPD patients,122 were developed from chronic bronchitis and 31

Abstract:Objective To investigate the correlation between arterial remodeling and different circadian blood pressure rhythms in patients with essential hypertension by comparing parameters of the arterial remodeling between the dipper and non-dipper hypertensive p

Abstract:Objective To evaluate the therapeutic effectiveness and safety of coronary bifurcation stenting in patients with coronary heart disease. Methods Data of 74 patients with coronary bifurcation lesion treated with coronary stenting in this hospital from Jan.

Abstract:目的从细胞水平了解肾上腺素受体对基质金属蛋白酶（MMP）的调控机制。方法构建含MMP-9启动子区的乙酰基转移酶（CAT）报告基因质粒，转染人脐静脉内皮细胞系ECV304细胞，测定肾上腺素受体激动剂刺激后报告基因的CAT活性。结果重组质粒转染ECV304细胞后，加入苯肾上腺素（PE，α肾上腺素受体激动剂）和异丙肾上腺素（ISO，β肾上腺素受体激动剂）后，含MMP-9启动子区域（-1285～＋1）和截短（-523～＋1）区域的转染细胞报告基因表达上调，但前者更为明显。PE与ISO的反应强度和变化曲线有较大差异，ISO峰值在4h反应强度为80倍，而PE为逐步上升，至24h达到最大值。结论肾上腺素受体与MMP活性之间存在着明显的相关性，为老年心血管病的进一步临床和实验研究提供了信息。

Abstract:Objective To reveal the origin of evolution and development of atrial fibrillation through the observation of cardiac electric activity character in the very early developmental stage of chick embryo. Methods The EPS electrocardiograph analyzer was used t

Abstract:目的从细胞瞬时外向钾电流(Ito)角度,探讨地黄低聚糖(RGOs)对骨骼肌成肌细胞(SMs)电生理特性的影响。方法分离成年大鼠心肌细胞和SMs,运用膜片钳技术研究心肌细胞和SMs以及0.625g·L-1RGOs干预后,SMs与心肌细胞Ito的差异。结果两种细胞Ito均从-40mV时开始激活,RGOs对大鼠SMsIto有增加作用,从-30mV到30mV,经过0.625g·L-1RGOs预处理的SMs组Ito密度〔(7.3±0.7)to(65.3±2.3)pA/pF(n=5)〕显著高于心肌组〔(0.9±0.1)to(28.8±0.9)pA/pF(n=5)〕和SMs组〔(4.5±0.5)to(23.7±2.0)pA/pF(n=5)〕的电流密度。结论RGOs能显著提高SMs的Ito密度,影响移植的SMs的电生理特性。这为今后在提高干细胞移植有效性同时,增加其安全性提供了一个新的思路。

Abstract:Objective To find mimetic peptides which bind specifically with triggering receptor expressed on myeloid cells-1 (TREM-1) and inhibit the TREM-1 pathway. Methods The functioning region of TREM-1 protein was cloned,expressed and purified. With the recombin