Research progress on ketone oxidative metabolism in cardiovascular diseases
Author:
Affiliation:

(1.Department of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia Co-Founded by Province and Ministry, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China;2.Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi 830054, China;3.Clinical Medical Research Institute, Xinjiang Medical University, Urumqi 830054, China)

Fund Project:

This work was supported by the National Natural Science Foundation of China (82060073, 81870272), Youth Science and Technology Elite Talent Program of Xinjiang Medical University ( XYD2024Q03 ) and the Open Topic Project of Xinjiang Key Laboratory (2020D04027, 2021D04020).

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    Abstract:

    Cardiovascular disease is a leading cause of death worldwide, characterized by high morbidity, high mortality, high disability rate, and high recurrence rates. In physiological condition, the heart primarily relies on the oxidative metabolism of fatty acids and glucose to generate energy. However, in various pathological conditions, such as myocardial infarction and heart failure, the metabolic pathways for fatty acids and glucose in cardiomyocytes become impaired. In these situations, ketone bodies emerge as an alternative ‘super-fuel’ for the heart′s energy supply. In this article, we reviewed the role and mechanism of ketone body metabolism in cardiovascular diseases based on the latest reports.

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History
  • Received:April 10,2024
  • Online: February 17,2025
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