As the global population aging, the health concerns of the elderly are attracting more and more attention. Due to the declines of physiological functions, the elderly are highly prone to comorbidity and frailty, which leads to a decrease in their quality of life, reduced self-care capability, increased hospitalization rates and higher mortality risk. The occurrence of frailty in elderly patients with comorbidities is related to various factors, including demographic characteristics such as advanced age and education level, as well as social factors like malnutrition, lack of exercise and psychological stress. Interventions for comorbidity and frailty mainly include nutritional supplementation, physical exercise and psychosocial support for the elderly. These measures are of great clinical importance in slowing the progression of frailty and improving comorbidity management. In this article, we review the influencing factors and interventional measures for comorbidity and frailty in the elderly, aiming to provide a reference for clinical healthcare profe-ssionals to take effective measures for the prevention and management of frailty.