Objective To investigate the clinicopathological characteristics of idiopathic membranous nephropathy (IMN) complicated with glomerulosclerosis and to analyze the relevant factors for the formation of glomerulosclerosis. Methods A retrospective analysis was performed on 430 IMN patients diagnosed by renal puncture biopsy in Department of Nephrology of Guangdong Provincial Hospital of Traditional Chinese Medicine from January 2012 to December 2021. According to complication of glomerulosclerosis or not, they were divided into two groups, and the clinicopathological features were compared between the IMN patients with glomerulosclerosis and those without. SPSS statistics 25.0 was used for statistical analysis. Data comparison between two groups was performed usingt test, Mann-Whitney U test, χ²test or Fisher′s exact probability test depending on data type. Results Of the 430 patients with IMN, 252 (58.6%) had concomitant glomerulosclerosis. The patients complicated with glomerulosclerosis had significantly longer course of disease, older age, larger proportions of hypertension and diabetes mellitus, and higher serum creatinine (SCr) level, but lower estimated glomerular filtration rate (eGFR) and hemoglobin (Hb) level when compared to those without glomerulosclerosis (P<0.05). Univariate logistic regression analysis indicated that age, course of disease, hypertension, diabetes melitus, Hb, SCr, eGFR, blood urine nitrogen, renal tubular atrophy and interstitial fibrosis were related influencing factors of glomerulosclerosis in IMN patients (P<0.05). Multivariate logistic regression analysis suggested that age (OR=1.047,95%CI 1.022-1.072; P<0.001), hypertension (OR=2.079,95%CI 1.211-3.570; P=0.008) and interstitial fibrosis (OR=2.564,95%CI 1.382-4.755; P=0.003) were associated with glomerulosclerosis formation. Conclusion IMN patients with concomitant glomerulosclerosis are in more serious conditions, and age, hypertension and interstitial fibrosis are independent influencing factors for glomerulosclerosis. In clinical practice, for the IMN patients with identified glomerulosclerosis in renal puncture biopsy, clinicians should strengthen the monitoring of renal function related indicators and actively treat and evaluate the progression of IMN.