With the deepening of aging population in China, frailty, as a common geriatric syndrome, has become a new prominent problem in public health. Heart failure and frailty often coexist in the elderly, leading to a variety of adverse clinical outcomes. It is of vital importance of profoundly investigating the pathogenesis, summarizing the influencing factors, and exploring effective intervention measures so as to improve the quality of life and prognosis of these patients. Therefore, in this article, we elucidate the pathophysiological mechanism and influencing factors based on relevant research progress, and review the intervention measures, so as to provide a reference for the development of intervention programs for elderly people with heart failure and frailty.