Sepsis is frequently associated with hemodynamic instability and complicated pathophysiological process. Its hemodynamic treatment aims aimed to restore microcirculatory perfusion, ensure oxygen uptake rate of tissue cells, protect cardiac function, and promote early repair of cardiomyocytes, thereby improving the patient′s prognosis. However, no specific drug is available for the treatment of hemodynamic disorders in sepsis. The Traditional Chinese Medicine (TCM) offers theoretical basis of intervention in sepsis. This article reviews the current cognition of hemodynamic disorders in sepsis and the feasibility of TCM intervention, hoping to provide new insights and directions for its clinical treatment.