Research progress in mechanisms of P2X7 receptor-mediated osteoporosis

doi:10.11915/j.issn.1671-5403.2023.03.046

Home > Archive>Volume 22, Issue 3, 2023 >222-226. DOI:10.11915/j.issn.1671-5403.2023.03.046

Research progress in mechanisms of P2X7 receptor-mediated osteoporosis
DOI:
                        10.11915/j.issn.1671-5403.2023.03.046
                    
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Author:
                        Zhang Chunlan1Zhang Chunlan
School of Acupuncture and Massage, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China
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Yang Feng2Yang Feng
Department of Bone Diseases, First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China
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Yuan Puwei2Yuan Puwei
Department of Bone Diseases, First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China
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Zheng Jie1Zheng Jie
School of Acupuncture and Massage, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China
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Affiliation:(1. School of Acupuncture and Massage, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China;2. Department of Bone Diseases, First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China)
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Fund Project:This work was supported by the General Programs in the Key Research and Development Plan of Shaanxi Provincial Department of Science and Technology ( 2022SF- 184), Youth Innovation Team Project in Scientific Research of Shaanxi Provincial Education Department (21JP034) and Youth Innovation Team Project of Shaanxi University

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Abstract:

Osteoporosis is a systemic metabolic disease with the defective coupling of bone resorption and bone reconstruction, resulting in imbalance of calcium and phosphorus metabolism and gradual reduction of bone density. Purinergic ligand-gated ion channel 7 receptor (P2X7R) are highly expressed in osteocyte, regulating continuous absorption and remodeling of the skeletal system. P2X7R activation is associated with osteoclast formation and reabsorption and with osteoblast differentiation. P2X7R can also influence bone loss by stimulating immune cells during inflammatory response. This article reviews the research progress of P2X7R in osteoporosis in recent years, providing evidence for the pathogenesis of osteoporosis and the development of new drugs.

Key words:osteoporosis; P2X7R; osteoclasts; osteoblasts

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Received:May 13,2022
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Online: March 29,2023
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